Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments

We report an essential role for the ras-related small GTP-binding protein rab1b in vesicular transport in mammalian cells. mAbs detect rab1b in both the ER and Golgi compartments. Using an assay which reconstitutes transport between the ER and the cis-Golgi compartment, we find that rab1b is require...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1991
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289927/
https://www.ncbi.nlm.nih.gov/pubmed/1918138
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description We report an essential role for the ras-related small GTP-binding protein rab1b in vesicular transport in mammalian cells. mAbs detect rab1b in both the ER and Golgi compartments. Using an assay which reconstitutes transport between the ER and the cis-Golgi compartment, we find that rab1b is required during an initial step in export of protein from the ER. In addition, it is also required for transport of protein between successive cis- and medial-Golgi compartments. We suggest that rab1b may provide a common link between upstream and downstream components of the vesicular fission and fusion machinery functioning in early compartments of the secretory pathway.
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spelling pubmed-22899272008-05-01 Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments J Cell Biol Articles We report an essential role for the ras-related small GTP-binding protein rab1b in vesicular transport in mammalian cells. mAbs detect rab1b in both the ER and Golgi compartments. Using an assay which reconstitutes transport between the ER and the cis-Golgi compartment, we find that rab1b is required during an initial step in export of protein from the ER. In addition, it is also required for transport of protein between successive cis- and medial-Golgi compartments. We suggest that rab1b may provide a common link between upstream and downstream components of the vesicular fission and fusion machinery functioning in early compartments of the secretory pathway. The Rockefeller University Press 1991-10-01 /pmc/articles/PMC2289927/ /pubmed/1918138 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments
title Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments
title_full Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments
title_fullStr Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments
title_full_unstemmed Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments
title_short Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments
title_sort rab1b regulates vesicular transport between the endoplasmic reticulum and successive golgi compartments
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289927/
https://www.ncbi.nlm.nih.gov/pubmed/1918138

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