A transient benign lymph node-based proliferation of T-cells simulating non-Hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha and CD11a antagonists

BACKGROUND: Therapeutic biologic agents are uncommonly associated with lymphoma. CASE PRESENTATION: We report a patient with psoriasis treated with the biologic agents efalizumab (Raptiva(®)) and etanercept (Enbrel(®)), who developed painless lymphadenopathy with peripheral lymphocytosis during trea...

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Autores principales: Hurley, M Yadira, George, Mary Noel, Leonardi, Craig L, Frater, John L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291032/
https://www.ncbi.nlm.nih.gov/pubmed/18366773
http://dx.doi.org/10.1186/1746-1596-3-13
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author Hurley, M Yadira
George, Mary Noel
Leonardi, Craig L
Frater, John L
author_facet Hurley, M Yadira
George, Mary Noel
Leonardi, Craig L
Frater, John L
author_sort Hurley, M Yadira
collection PubMed
description BACKGROUND: Therapeutic biologic agents are uncommonly associated with lymphoma. CASE PRESENTATION: We report a patient with psoriasis treated with the biologic agents efalizumab (Raptiva(®)) and etanercept (Enbrel(®)), who developed painless lymphadenopathy with peripheral lymphocytosis during treatment, simulating a non-Hodgkin lymphoma clinically and pathologically. Lymphocytosis and lymphadenopathy spontaneously remitted following cessation of etanercept therapy and have not recurred. CONCLUSION: Distinction between clinically benign lymphoid proliferations related to antipsoriasis therapy and malignant lymphoma avoids the unnecessary use of anti-lymphoma chemotherapy.
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spelling pubmed-22910322008-04-09 A transient benign lymph node-based proliferation of T-cells simulating non-Hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha and CD11a antagonists Hurley, M Yadira George, Mary Noel Leonardi, Craig L Frater, John L Diagn Pathol Case Report BACKGROUND: Therapeutic biologic agents are uncommonly associated with lymphoma. CASE PRESENTATION: We report a patient with psoriasis treated with the biologic agents efalizumab (Raptiva(®)) and etanercept (Enbrel(®)), who developed painless lymphadenopathy with peripheral lymphocytosis during treatment, simulating a non-Hodgkin lymphoma clinically and pathologically. Lymphocytosis and lymphadenopathy spontaneously remitted following cessation of etanercept therapy and have not recurred. CONCLUSION: Distinction between clinically benign lymphoid proliferations related to antipsoriasis therapy and malignant lymphoma avoids the unnecessary use of anti-lymphoma chemotherapy. BioMed Central 2008-03-26 /pmc/articles/PMC2291032/ /pubmed/18366773 http://dx.doi.org/10.1186/1746-1596-3-13 Text en Copyright © 2008 Hurley et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hurley, M Yadira
George, Mary Noel
Leonardi, Craig L
Frater, John L
A transient benign lymph node-based proliferation of T-cells simulating non-Hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha and CD11a antagonists
title A transient benign lymph node-based proliferation of T-cells simulating non-Hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha and CD11a antagonists
title_full A transient benign lymph node-based proliferation of T-cells simulating non-Hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha and CD11a antagonists
title_fullStr A transient benign lymph node-based proliferation of T-cells simulating non-Hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha and CD11a antagonists
title_full_unstemmed A transient benign lymph node-based proliferation of T-cells simulating non-Hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha and CD11a antagonists
title_short A transient benign lymph node-based proliferation of T-cells simulating non-Hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha and CD11a antagonists
title_sort transient benign lymph node-based proliferation of t-cells simulating non-hodgkin lymphoma in a patient with psoriasis treated with tumor necrosis factor alpha and cd11a antagonists
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291032/
https://www.ncbi.nlm.nih.gov/pubmed/18366773
http://dx.doi.org/10.1186/1746-1596-3-13
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