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‘Real-life’ reduction in cholesterol with statins, 1993 to 2002

AIMS: To evaluate the impact of lipid-lowering treatment on cholesterol concentrations in the setting of normal care. METHODS: This was a retrospective review of all cholesterol measurements made in Tayside, Scotland, between 1993 and 2002, linked to dispensed prescribing data for lipid-lowering dru...

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Autores principales: Murphy, Michael J, Wei, Li, Watson, Alexander D, MacDonald, Thomas M
Formato: Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291374/
https://www.ncbi.nlm.nih.gov/pubmed/18241286
http://dx.doi.org/10.1111/j.1365-2125.2007.03066.x
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author Murphy, Michael J
Wei, Li
Watson, Alexander D
MacDonald, Thomas M
author_facet Murphy, Michael J
Wei, Li
Watson, Alexander D
MacDonald, Thomas M
author_sort Murphy, Michael J
collection PubMed
description AIMS: To evaluate the impact of lipid-lowering treatment on cholesterol concentrations in the setting of normal care. METHODS: This was a retrospective review of all cholesterol measurements made in Tayside, Scotland, between 1993 and 2002, linked to dispensed prescribing data for lipid-lowering drugs. It was conducted in the setting of normal care and included all patients who underwent cholesterol measurement. The main outcome measure was cholesterol concentration. RESULTS: A total of 401 489 cholesterol measurements were made on 128 240 patients over the study period. Measurements were categorized as treated and untreated according to whether patients were exposed to lipid-lowering treatment at the time the total cholesterol concentration was measured. Those categorized as untreated fell by 0.86 mmol l(−1) (13.9%) and those categorized as treated by 1.45 mmol l(−1) (23.5%). The difference between baseline and follow-up cholesterol concentrations in intention-to-treat patients was 1.53 mmol l(−1) (24%) in 2002. In the same year, mean cholesterol concentration was 4.71 mmol l(−1) (a fall of 1.65 mmol l(−1) or 25.9%) in patients judged to be taking their lipid-lowering medication, compared with 5.20 mmol l(−1) (a fall of 1.16 mmol l(−1) or 18.2%) in those judged not to be taking treatment. Cholesterol fell by 0.38 mmol l(−1) (6.3%) in a cohort of never treated patients (n = 33 679) between 1993 and 2002. CONCLUSIONS: The impact of lipid-lowering drugs on population cholesterol concentrations in the setting of normal care was significant and comparable with the cholesterol reductions seen in the setting of major statin trials, despite a significant proportion of the population receiving low dose treatment. In those subjects judged to be taking their medication, the benefits achieved were substantial. The impact of nondrug factors is indicated by the fall in population cholesterol seen in the absence of lipid-lowering treatment.
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spelling pubmed-22913742009-04-01 ‘Real-life’ reduction in cholesterol with statins, 1993 to 2002 Murphy, Michael J Wei, Li Watson, Alexander D MacDonald, Thomas M Br J Clin Pharmacol Pharmacoepidemiology AIMS: To evaluate the impact of lipid-lowering treatment on cholesterol concentrations in the setting of normal care. METHODS: This was a retrospective review of all cholesterol measurements made in Tayside, Scotland, between 1993 and 2002, linked to dispensed prescribing data for lipid-lowering drugs. It was conducted in the setting of normal care and included all patients who underwent cholesterol measurement. The main outcome measure was cholesterol concentration. RESULTS: A total of 401 489 cholesterol measurements were made on 128 240 patients over the study period. Measurements were categorized as treated and untreated according to whether patients were exposed to lipid-lowering treatment at the time the total cholesterol concentration was measured. Those categorized as untreated fell by 0.86 mmol l(−1) (13.9%) and those categorized as treated by 1.45 mmol l(−1) (23.5%). The difference between baseline and follow-up cholesterol concentrations in intention-to-treat patients was 1.53 mmol l(−1) (24%) in 2002. In the same year, mean cholesterol concentration was 4.71 mmol l(−1) (a fall of 1.65 mmol l(−1) or 25.9%) in patients judged to be taking their lipid-lowering medication, compared with 5.20 mmol l(−1) (a fall of 1.16 mmol l(−1) or 18.2%) in those judged not to be taking treatment. Cholesterol fell by 0.38 mmol l(−1) (6.3%) in a cohort of never treated patients (n = 33 679) between 1993 and 2002. CONCLUSIONS: The impact of lipid-lowering drugs on population cholesterol concentrations in the setting of normal care was significant and comparable with the cholesterol reductions seen in the setting of major statin trials, despite a significant proportion of the population receiving low dose treatment. In those subjects judged to be taking their medication, the benefits achieved were substantial. The impact of nondrug factors is indicated by the fall in population cholesterol seen in the absence of lipid-lowering treatment. Blackwell Science Inc 2008-04 2008-02-20 /pmc/articles/PMC2291374/ /pubmed/18241286 http://dx.doi.org/10.1111/j.1365-2125.2007.03066.x Text en © 2008 The Authors Journal compilation © 2008 Blackwell Publishing Ltd https://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Pharmacoepidemiology
Murphy, Michael J
Wei, Li
Watson, Alexander D
MacDonald, Thomas M
‘Real-life’ reduction in cholesterol with statins, 1993 to 2002
title ‘Real-life’ reduction in cholesterol with statins, 1993 to 2002
title_full ‘Real-life’ reduction in cholesterol with statins, 1993 to 2002
title_fullStr ‘Real-life’ reduction in cholesterol with statins, 1993 to 2002
title_full_unstemmed ‘Real-life’ reduction in cholesterol with statins, 1993 to 2002
title_short ‘Real-life’ reduction in cholesterol with statins, 1993 to 2002
title_sort ‘real-life’ reduction in cholesterol with statins, 1993 to 2002
topic Pharmacoepidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291374/
https://www.ncbi.nlm.nih.gov/pubmed/18241286
http://dx.doi.org/10.1111/j.1365-2125.2007.03066.x
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