Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: Varying the number of double-stranded RNA binding domains and lineage-specific duplications

BACKGROUND: Double-stranded (ds) RNA, generated during viral infection, binds and activates the mammalian anti-viral protein kinase PKR, which phosphorylates the translation initiation factor eIF2α leading to the general inhibition of protein synthesis. Although PKR-like activity has been described...

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Detalles Bibliográficos
Autores principales: Rothenburg, Stefan, Deigendesch, Nikolaus, Dey, Madhusudan, Dever, Thomas E, Tazi, Loubna
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291453/
https://www.ncbi.nlm.nih.gov/pubmed/18312693
http://dx.doi.org/10.1186/1741-7007-6-12

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