Treg Depletion Inhibits Efficacy of Cancer Immunotherapy: Implications for Clinical Trials

BACKGROUND: Regulatory T lymphocytes (Treg) infiltrate human glioblastoma (GBM); are involved in tumor progression and correlate with tumor grade. Transient elimination of Tregs using CD25 depleting antibodies (PC61) has been found to mediate GBM regression in preclinical models of brain tumors. Cli...

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Detalles Bibliográficos
Autores principales: Curtin, James F., Candolfi, Marianela, Fakhouri, Tamer M., Liu, Chunyan, Alden, Anderson, Edwards, Matthew, Lowenstein, Pedro R., Castro, Maria G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291560/
https://www.ncbi.nlm.nih.gov/pubmed/18431473
http://dx.doi.org/10.1371/journal.pone.0001983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291560/
https://www.ncbi.nlm.nih.gov/pubmed/18431473
http://dx.doi.org/10.1371/journal.pone.0001983

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