Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1

BACKGROUND: Overexpression of the human DYRK1A gene due to the presence of a third gene copy in trisomy 21 is thought to play a role in the pathogenesis of Down syndrome. The observation of gene dosage effects in transgenic mouse models implies that subtle changes in expression levels can affect the...

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Detalles Bibliográficos
Autores principales: Maenz, Barbara, Hekerman, Paul, Vela, Eva M, Galceran, Juan, Becker, Walter
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292204/
https://www.ncbi.nlm.nih.gov/pubmed/18366763
http://dx.doi.org/10.1186/1471-2199-9-30

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292204/
https://www.ncbi.nlm.nih.gov/pubmed/18366763
http://dx.doi.org/10.1186/1471-2199-9-30

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