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Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1
BACKGROUND: Overexpression of the human DYRK1A gene due to the presence of a third gene copy in trisomy 21 is thought to play a role in the pathogenesis of Down syndrome. The observation of gene dosage effects in transgenic mouse models implies that subtle changes in expression levels can affect the...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292204/ https://www.ncbi.nlm.nih.gov/pubmed/18366763 http://dx.doi.org/10.1186/1471-2199-9-30 |