The role of CTCF in regulating nuclear organization

The spatial organization of the genome is thought to play an important part in the coordination of gene regulation. New techniques have been used to identify specific long-range interactions between distal DNA sequences, revealing an ever-increasing complexity to nuclear organization. CCCTC-binding...

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Detalles Bibliográficos
Autores principales: Williams, Adam, Flavell, Richard A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292214/
https://www.ncbi.nlm.nih.gov/pubmed/18347103
http://dx.doi.org/10.1084/jem.20080066
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author Williams, Adam
Flavell, Richard A.
author_facet Williams, Adam
Flavell, Richard A.
author_sort Williams, Adam
collection PubMed
description The spatial organization of the genome is thought to play an important part in the coordination of gene regulation. New techniques have been used to identify specific long-range interactions between distal DNA sequences, revealing an ever-increasing complexity to nuclear organization. CCCTC-binding factor (CTCF) is a versatile zinc finger protein with diverse regulatory functions. New data now help define how CTCF mediates both long-range intrachromosomal and interchromosomal interactions, and highlight CTCF as an important factor in determining the three-dimensional structure of the genome.
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spelling pubmed-22922142008-10-14 The role of CTCF in regulating nuclear organization Williams, Adam Flavell, Richard A. J Exp Med Commentaries The spatial organization of the genome is thought to play an important part in the coordination of gene regulation. New techniques have been used to identify specific long-range interactions between distal DNA sequences, revealing an ever-increasing complexity to nuclear organization. CCCTC-binding factor (CTCF) is a versatile zinc finger protein with diverse regulatory functions. New data now help define how CTCF mediates both long-range intrachromosomal and interchromosomal interactions, and highlight CTCF as an important factor in determining the three-dimensional structure of the genome. The Rockefeller University Press 2008-04-14 /pmc/articles/PMC2292214/ /pubmed/18347103 http://dx.doi.org/10.1084/jem.20080066 Text en Copyright © 2008, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Williams, Adam
Flavell, Richard A.
The role of CTCF in regulating nuclear organization
title The role of CTCF in regulating nuclear organization
title_full The role of CTCF in regulating nuclear organization
title_fullStr The role of CTCF in regulating nuclear organization
title_full_unstemmed The role of CTCF in regulating nuclear organization
title_short The role of CTCF in regulating nuclear organization
title_sort role of ctcf in regulating nuclear organization
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292214/
https://www.ncbi.nlm.nih.gov/pubmed/18347103
http://dx.doi.org/10.1084/jem.20080066
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