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Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen
B cell receptor (BCR) recognition of membrane-bound antigen initiates a spreading and contraction response, the extent of which is controlled through the formation of signaling-active BCR-antigen microclusters and ultimately affects the outcome of B cell activation. We followed a genetic approach to...
Autores principales: | Weber, Michele, Treanor, Bebhinn, Depoil, David, Shinohara, Hisaaki, Harwood, Naomi E., Hikida, Masaki, Kurosaki, Tomohiro, Batista, Facundo D. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292224/ https://www.ncbi.nlm.nih.gov/pubmed/18362175 http://dx.doi.org/10.1084/jem.20072619 |
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