Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

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B cell receptor (BCR) recognition of membrane-bound antigen initiates a spreading and contraction response, the extent of which is controlled through the formation of signaling-active BCR-antigen microclusters and ultimately affects the outcome of B cell activation. We followed a genetic approach to...

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Detalles Bibliográficos
Autores principales: Weber, Michele, Treanor, Bebhinn, Depoil, David, Shinohara, Hisaaki, Harwood, Naomi E., Hikida, Masaki, Kurosaki, Tomohiro, Batista, Facundo D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292224/
https://www.ncbi.nlm.nih.gov/pubmed/18362175
http://dx.doi.org/10.1084/jem.20072619
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