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Early changes in arterial structure and function following statin initiation: Quantification by magnetic resonance imaging

Effective LDL-cholesterol (LDL-C) reduction improves vascular function and can bring about regression of atherosclerosis. Alterations in endothelial function can occur rapidly, but changes in atherosclerosis are generally considered to occur more slowly. Vascular magnetic resonance imaging (MRI) is...

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Autores principales: Lee, Justin M.S., Wiesmann, Frank, Shirodaria, Cheerag, Leeson, Paul, Petersen, Steffen E., Francis, Jane M., Jackson, Clare E., Robson, Matthew D., Neubauer, Stefan, Channon, Keith M., Choudhury, Robin P.
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292239/
https://www.ncbi.nlm.nih.gov/pubmed/17977546
http://dx.doi.org/10.1016/j.atherosclerosis.2007.09.001
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author Lee, Justin M.S.
Wiesmann, Frank
Shirodaria, Cheerag
Leeson, Paul
Petersen, Steffen E.
Francis, Jane M.
Jackson, Clare E.
Robson, Matthew D.
Neubauer, Stefan
Channon, Keith M.
Choudhury, Robin P.
author_facet Lee, Justin M.S.
Wiesmann, Frank
Shirodaria, Cheerag
Leeson, Paul
Petersen, Steffen E.
Francis, Jane M.
Jackson, Clare E.
Robson, Matthew D.
Neubauer, Stefan
Channon, Keith M.
Choudhury, Robin P.
author_sort Lee, Justin M.S.
collection PubMed
description Effective LDL-cholesterol (LDL-C) reduction improves vascular function and can bring about regression of atherosclerosis. Alterations in endothelial function can occur rapidly, but changes in atherosclerosis are generally considered to occur more slowly. Vascular magnetic resonance imaging (MRI) is a powerful technique for accurate non-invasive assessment of central and peripheral arteries at multiple anatomical sites. We report the changes in atherosclerosis burden and arterial function in response to open label statin treatment, in 24 statin-naïve newly diagnosed stable coronary artery disease patients. Patients underwent MRI before, and 3 and 12 months after commencing treatment. Mean LDL-C fell by 37% to 70.8 mg/dL (P < 0.01). The plaque index (normalised vessel wall area) showed reductions in the aorta (2.3%, P < 0.05) and carotid (3.1%, P < 0.05) arteries at 3 months. Early reductions in atherosclerosis of aorta and carotid observed at 3 months were significantly correlated with later change at 12 months (R(2) = 0.50, P < 0.001; R(2) = 0.22, P < 0.05, respectively). Improvements in aortic distensibility and brachial endothelial function that were apparent after 3 months treatment were sustained at the 12-month time point.
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spelling pubmed-22922392008-05-08 Early changes in arterial structure and function following statin initiation: Quantification by magnetic resonance imaging Lee, Justin M.S. Wiesmann, Frank Shirodaria, Cheerag Leeson, Paul Petersen, Steffen E. Francis, Jane M. Jackson, Clare E. Robson, Matthew D. Neubauer, Stefan Channon, Keith M. Choudhury, Robin P. Atherosclerosis Article Effective LDL-cholesterol (LDL-C) reduction improves vascular function and can bring about regression of atherosclerosis. Alterations in endothelial function can occur rapidly, but changes in atherosclerosis are generally considered to occur more slowly. Vascular magnetic resonance imaging (MRI) is a powerful technique for accurate non-invasive assessment of central and peripheral arteries at multiple anatomical sites. We report the changes in atherosclerosis burden and arterial function in response to open label statin treatment, in 24 statin-naïve newly diagnosed stable coronary artery disease patients. Patients underwent MRI before, and 3 and 12 months after commencing treatment. Mean LDL-C fell by 37% to 70.8 mg/dL (P < 0.01). The plaque index (normalised vessel wall area) showed reductions in the aorta (2.3%, P < 0.05) and carotid (3.1%, P < 0.05) arteries at 3 months. Early reductions in atherosclerosis of aorta and carotid observed at 3 months were significantly correlated with later change at 12 months (R(2) = 0.50, P < 0.001; R(2) = 0.22, P < 0.05, respectively). Improvements in aortic distensibility and brachial endothelial function that were apparent after 3 months treatment were sustained at the 12-month time point. Elsevier 2008-04 /pmc/articles/PMC2292239/ /pubmed/17977546 http://dx.doi.org/10.1016/j.atherosclerosis.2007.09.001 Text en © 2008 Elsevier Ireland Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Lee, Justin M.S.
Wiesmann, Frank
Shirodaria, Cheerag
Leeson, Paul
Petersen, Steffen E.
Francis, Jane M.
Jackson, Clare E.
Robson, Matthew D.
Neubauer, Stefan
Channon, Keith M.
Choudhury, Robin P.
Early changes in arterial structure and function following statin initiation: Quantification by magnetic resonance imaging
title Early changes in arterial structure and function following statin initiation: Quantification by magnetic resonance imaging
title_full Early changes in arterial structure and function following statin initiation: Quantification by magnetic resonance imaging
title_fullStr Early changes in arterial structure and function following statin initiation: Quantification by magnetic resonance imaging
title_full_unstemmed Early changes in arterial structure and function following statin initiation: Quantification by magnetic resonance imaging
title_short Early changes in arterial structure and function following statin initiation: Quantification by magnetic resonance imaging
title_sort early changes in arterial structure and function following statin initiation: quantification by magnetic resonance imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292239/
https://www.ncbi.nlm.nih.gov/pubmed/17977546
http://dx.doi.org/10.1016/j.atherosclerosis.2007.09.001
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