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The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever
Colchicine is the treatment of choice in familial Mediterranean fever (FMF) for the prevention of both attacks and secondary amyloidosis. The overall nonresponder rate is about 5–10%. Anakinra is known to have good effectiveness in a severe autoinflammatory syndrome [chronic infantile neurological c...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer-Verlag
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292480/ https://www.ncbi.nlm.nih.gov/pubmed/17588171 http://dx.doi.org/10.1007/s00431-007-0547-3 |
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author | Calligaris, Lorenzo Marchetti, Federico Tommasini, Alberto Ventura, Alessandro |
author_facet | Calligaris, Lorenzo Marchetti, Federico Tommasini, Alberto Ventura, Alessandro |
author_sort | Calligaris, Lorenzo |
collection | PubMed |
description | Colchicine is the treatment of choice in familial Mediterranean fever (FMF) for the prevention of both attacks and secondary amyloidosis. The overall nonresponder rate is about 5–10%. Anakinra is known to have good effectiveness in a severe autoinflammatory syndrome [chronic infantile neurological cutaneous and articular (CINCA) syndrome] and other recurrent hereditary periodic fevers. Pyrin—the protein involved in FMF—has a role in activating the proinflammatory cytokine interleukin (IL)-1β. We report the effectiveness of the addition of an IL-1-receptor inhibitor (anakinra) to colchicine in controlling the febrile attacks and acute phase response in an adolescent with FMF resistant to colchicine. |
format | Text |
id | pubmed-2292480 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-22924802008-04-11 The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever Calligaris, Lorenzo Marchetti, Federico Tommasini, Alberto Ventura, Alessandro Eur J Pediatr Short Report Colchicine is the treatment of choice in familial Mediterranean fever (FMF) for the prevention of both attacks and secondary amyloidosis. The overall nonresponder rate is about 5–10%. Anakinra is known to have good effectiveness in a severe autoinflammatory syndrome [chronic infantile neurological cutaneous and articular (CINCA) syndrome] and other recurrent hereditary periodic fevers. Pyrin—the protein involved in FMF—has a role in activating the proinflammatory cytokine interleukin (IL)-1β. We report the effectiveness of the addition of an IL-1-receptor inhibitor (anakinra) to colchicine in controlling the febrile attacks and acute phase response in an adolescent with FMF resistant to colchicine. Springer-Verlag 2007-06-23 2008-06 /pmc/articles/PMC2292480/ /pubmed/17588171 http://dx.doi.org/10.1007/s00431-007-0547-3 Text en © Springer-Verlag 2007 |
spellingShingle | Short Report Calligaris, Lorenzo Marchetti, Federico Tommasini, Alberto Ventura, Alessandro The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever |
title | The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever |
title_full | The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever |
title_fullStr | The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever |
title_full_unstemmed | The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever |
title_short | The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever |
title_sort | efficacy of anakinra in an adolescent with colchicine-resistant familial mediterranean fever |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292480/ https://www.ncbi.nlm.nih.gov/pubmed/17588171 http://dx.doi.org/10.1007/s00431-007-0547-3 |
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