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Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer

The folate derivatives folic acid (FA) and folinic acid (FNA) decrease the in vivo and in vitro activities of antifolate drugs in Plasmodium falciparum. However, the effects of 5-methyl-tetrahydrofolate (5-Me-THF) and tetrahydrofolate (THF), the two dominant circulating folate forms in humans, have...

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Detalles Bibliográficos
Autores principales:	Nduati, Eunice, Diriye, Abdi, Ommeh, Sheila, Mwai, Leah, Kiara, Steven, Masseno, Victor, Kokwaro, Gilbert, Nzila, Alexis
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2008
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292483/ https://www.ncbi.nlm.nih.gov/pubmed/18259776 http://dx.doi.org/10.1007/s00436-008-0897-4

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