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Ischemic stroke incidence in Santa Coloma de Gramenet (ISISCOG), Spain. A community-based study

BACKGROUND: In Spain, stroke is one of the major causes of death and the main cause of severe disability in people over 65 years. We analyzed the incidence of ischemic stroke, stroke subtypes, case fatality and disability at 90 days after the event in a Spanish population. METHODS: A prospective com...

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Autores principales: Alzamora, María Teresa, Sorribes, Marta, Heras, Antonio, Vila, Nicolás, Vicheto, Marisa, Forés, Rosa, Sánchez-Ojanguren, José, Sancho, Amparo, Pera, Guillem
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292741/
https://www.ncbi.nlm.nih.gov/pubmed/18371212
http://dx.doi.org/10.1186/1471-2377-8-5
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author Alzamora, María Teresa
Sorribes, Marta
Heras, Antonio
Vila, Nicolás
Vicheto, Marisa
Forés, Rosa
Sánchez-Ojanguren, José
Sancho, Amparo
Pera, Guillem
author_facet Alzamora, María Teresa
Sorribes, Marta
Heras, Antonio
Vila, Nicolás
Vicheto, Marisa
Forés, Rosa
Sánchez-Ojanguren, José
Sancho, Amparo
Pera, Guillem
author_sort Alzamora, María Teresa
collection PubMed
description BACKGROUND: In Spain, stroke is one of the major causes of death and the main cause of severe disability in people over 65 years. We analyzed the incidence of ischemic stroke, stroke subtypes, case fatality and disability at 90 days after the event in a Spanish population. METHODS: A prospective community-based register of ischemic strokes was established in Santa Coloma de Gramenet (Barcelona) [116,220 inhabitants of all ages, according to the municipal census of December 31,2001], from January 1 to December 31, 2003. Standard definitions and case finding methods were used to identify all cases in all age groups. Every patient underwent a complete clinical evaluation and systematic tests including neuroimaging (CT/MRI) and vascular studies (carotid duplex ultrasound intra and extracranial and MR angiography). RESULTS: Over a one year period, 196 ischemic strokes were registered [107 men; median age = 76 years (range 39–98)], being the first event in 159 patients (81.1%) and a recurrent stroke in 37 (18.9%). After age-adjustment to the European population, the incidence of ischemic stroke per 100,000 inhabitants was 172 (95% CI, 148–196); 219 (176–261) in men and 133 (105–160) in women, with an annual incidence for first ischemic stroke of 139 (118–161); 165 (128–201) in men and 115 (89–140) in women. The incidence of stroke increased with age. Stroke subtypes (TOAST classification criteria) were lacunar in 28.8%, atherothrombotic in 18.6%, cardioembolic in 26.6% and undetermined in 26.0% of patients. At 90 days, the case-fatality was 12%, and among survivors, moderate-to-severe disability was present in 45 % at 3 months. CONCLUSION: This prospective community-based study shows one of the lowest incidences of stroke in Europe, as well as one of the lowest case fatality and disability rates at 90 days after stroke.
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spelling pubmed-22927412008-04-12 Ischemic stroke incidence in Santa Coloma de Gramenet (ISISCOG), Spain. A community-based study Alzamora, María Teresa Sorribes, Marta Heras, Antonio Vila, Nicolás Vicheto, Marisa Forés, Rosa Sánchez-Ojanguren, José Sancho, Amparo Pera, Guillem BMC Neurol Research Article BACKGROUND: In Spain, stroke is one of the major causes of death and the main cause of severe disability in people over 65 years. We analyzed the incidence of ischemic stroke, stroke subtypes, case fatality and disability at 90 days after the event in a Spanish population. METHODS: A prospective community-based register of ischemic strokes was established in Santa Coloma de Gramenet (Barcelona) [116,220 inhabitants of all ages, according to the municipal census of December 31,2001], from January 1 to December 31, 2003. Standard definitions and case finding methods were used to identify all cases in all age groups. Every patient underwent a complete clinical evaluation and systematic tests including neuroimaging (CT/MRI) and vascular studies (carotid duplex ultrasound intra and extracranial and MR angiography). RESULTS: Over a one year period, 196 ischemic strokes were registered [107 men; median age = 76 years (range 39–98)], being the first event in 159 patients (81.1%) and a recurrent stroke in 37 (18.9%). After age-adjustment to the European population, the incidence of ischemic stroke per 100,000 inhabitants was 172 (95% CI, 148–196); 219 (176–261) in men and 133 (105–160) in women, with an annual incidence for first ischemic stroke of 139 (118–161); 165 (128–201) in men and 115 (89–140) in women. The incidence of stroke increased with age. Stroke subtypes (TOAST classification criteria) were lacunar in 28.8%, atherothrombotic in 18.6%, cardioembolic in 26.6% and undetermined in 26.0% of patients. At 90 days, the case-fatality was 12%, and among survivors, moderate-to-severe disability was present in 45 % at 3 months. CONCLUSION: This prospective community-based study shows one of the lowest incidences of stroke in Europe, as well as one of the lowest case fatality and disability rates at 90 days after stroke. BioMed Central 2008-03-27 /pmc/articles/PMC2292741/ /pubmed/18371212 http://dx.doi.org/10.1186/1471-2377-8-5 Text en Copyright © 2008 Alzamora et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Alzamora, María Teresa
Sorribes, Marta
Heras, Antonio
Vila, Nicolás
Vicheto, Marisa
Forés, Rosa
Sánchez-Ojanguren, José
Sancho, Amparo
Pera, Guillem
Ischemic stroke incidence in Santa Coloma de Gramenet (ISISCOG), Spain. A community-based study
title Ischemic stroke incidence in Santa Coloma de Gramenet (ISISCOG), Spain. A community-based study
title_full Ischemic stroke incidence in Santa Coloma de Gramenet (ISISCOG), Spain. A community-based study
title_fullStr Ischemic stroke incidence in Santa Coloma de Gramenet (ISISCOG), Spain. A community-based study
title_full_unstemmed Ischemic stroke incidence in Santa Coloma de Gramenet (ISISCOG), Spain. A community-based study
title_short Ischemic stroke incidence in Santa Coloma de Gramenet (ISISCOG), Spain. A community-based study
title_sort ischemic stroke incidence in santa coloma de gramenet (isiscog), spain. a community-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292741/
https://www.ncbi.nlm.nih.gov/pubmed/18371212
http://dx.doi.org/10.1186/1471-2377-8-5
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