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Childhood leukaemia incidence around French nuclear installations using geographic zoning based on gaseous discharge dose estimates

The present study investigated for the first time the incidence of childhood leukaemia (1990–2001) around French nuclear installations using a geographic zoning based on estimated doses to the red bone marrow due to gaseous radioactive discharges. The observed number of cases of acute leukaemia (O=7...

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Autores principales: Evrard, A-S, Hémon, D, Morin, A, Laurier, D, Tirmarche, M, Backe, J-C, Chartier, M, Clavel, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292746/
https://www.ncbi.nlm.nih.gov/pubmed/16622448
http://dx.doi.org/10.1038/sj.bjc.6603111
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author Evrard, A-S
Hémon, D
Morin, A
Laurier, D
Tirmarche, M
Backe, J-C
Chartier, M
Clavel, J
author_facet Evrard, A-S
Hémon, D
Morin, A
Laurier, D
Tirmarche, M
Backe, J-C
Chartier, M
Clavel, J
author_sort Evrard, A-S
collection PubMed
description The present study investigated for the first time the incidence of childhood leukaemia (1990–2001) around French nuclear installations using a geographic zoning based on estimated doses to the red bone marrow due to gaseous radioactive discharges. The observed number of cases of acute leukaemia (O=750) in 40 km(2) centred on 23 French nuclear installations between 1990 and 2001 was lower than expected (E=795.01), although not significantly so (standardised incidence ratio SIR=0.94, 95% confidence interval=(0.88–1.01)). In none of the five zones defined on the basis of the estimated doses was the SIR significantly >1. There was no evidence of a trend in SIR with the estimated doses for all the children or for any of the three age groups studied. This study confirmed that there was no evidence of an increased incidence of childhood leukaemia around the 23 French nuclear sites.
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spelling pubmed-22927462008-05-08 Childhood leukaemia incidence around French nuclear installations using geographic zoning based on gaseous discharge dose estimates Evrard, A-S Hémon, D Morin, A Laurier, D Tirmarche, M Backe, J-C Chartier, M Clavel, J Br J Cancer Epidemiology The present study investigated for the first time the incidence of childhood leukaemia (1990–2001) around French nuclear installations using a geographic zoning based on estimated doses to the red bone marrow due to gaseous radioactive discharges. The observed number of cases of acute leukaemia (O=750) in 40 km(2) centred on 23 French nuclear installations between 1990 and 2001 was lower than expected (E=795.01), although not significantly so (standardised incidence ratio SIR=0.94, 95% confidence interval=(0.88–1.01)). In none of the five zones defined on the basis of the estimated doses was the SIR significantly >1. There was no evidence of a trend in SIR with the estimated doses for all the children or for any of the three age groups studied. This study confirmed that there was no evidence of an increased incidence of childhood leukaemia around the 23 French nuclear sites. Nature Publishing Group 2006-05-08 2006-04-18 /pmc/articles/PMC2292746/ /pubmed/16622448 http://dx.doi.org/10.1038/sj.bjc.6603111 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Evrard, A-S
Hémon, D
Morin, A
Laurier, D
Tirmarche, M
Backe, J-C
Chartier, M
Clavel, J
Childhood leukaemia incidence around French nuclear installations using geographic zoning based on gaseous discharge dose estimates
title Childhood leukaemia incidence around French nuclear installations using geographic zoning based on gaseous discharge dose estimates
title_full Childhood leukaemia incidence around French nuclear installations using geographic zoning based on gaseous discharge dose estimates
title_fullStr Childhood leukaemia incidence around French nuclear installations using geographic zoning based on gaseous discharge dose estimates
title_full_unstemmed Childhood leukaemia incidence around French nuclear installations using geographic zoning based on gaseous discharge dose estimates
title_short Childhood leukaemia incidence around French nuclear installations using geographic zoning based on gaseous discharge dose estimates
title_sort childhood leukaemia incidence around french nuclear installations using geographic zoning based on gaseous discharge dose estimates
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292746/
https://www.ncbi.nlm.nih.gov/pubmed/16622448
http://dx.doi.org/10.1038/sj.bjc.6603111
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