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The link between neurosteroids and syndromic/syndromal components of the mood spectrum disorders in women during the premenstrual phase
OBJECTIVES: Females with a lifetime diagnosis of major mood disorder (Bipolar Disorder BD, Major Depressive Disorder MMD) investigated during the luteal phase of their menstrual cycle and in a condition of clinical well-being showed higher blood serum concentrations of progesterone and allopregnanol...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2311299/ https://www.ncbi.nlm.nih.gov/pubmed/18302757 http://dx.doi.org/10.1186/1745-0179-4-3 |
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author | Hardoy, Maria Carolina Sardu, Claudia Dell'Osso, Liliana Carta, Mauro Giovanni |
author_facet | Hardoy, Maria Carolina Sardu, Claudia Dell'Osso, Liliana Carta, Mauro Giovanni |
author_sort | Hardoy, Maria Carolina |
collection | PubMed |
description | OBJECTIVES: Females with a lifetime diagnosis of major mood disorder (Bipolar Disorder BD, Major Depressive Disorder MMD) investigated during the luteal phase of their menstrual cycle and in a condition of clinical well-being showed higher blood serum concentrations of progesterone and allopregnanolone compared to healthy controls. Women with BD presented even higher levels than those affected by MDD. This study attempted to verify, in line with a dimensional approach, if the possible differences in neurohormonal levels may be directly linked to some syndromal clusters (dimensions) of the mood spectrum disorders indipendently of diagnosis. METHODS: Premenstrual concentrations of allopregnanolone, THDOC, progesterone, and cortisol were measured in 3 groups of women: 17 BD and 14 MDD outpatients, and 16 control subjects. Psychiatric evaluation was performed with the SCID-I interview and the SCI-MOODS-SR questionnaire. The correlation between steroid levels and mood disorder syndromal cluster (SCI-MOODS-SR domains and sub-domains) was evaluated by means of analysis of main components with Varimax rotation and Kaiser's normalization (which provided for inclusion of all components with an Eigen value >1). RESULTS: Analysis of the main components evidenced the presence of 3 components: 1) mania, 2) depression both with mixed component 3) steroid + manic cognitivity and suicidal ideas. CONCLUSION: Levels of allopregnanolone and progesterone do not correlate with the association of the depressive and manic syndromes, but rather with mixed symptomatological aspects, and in particular with cognitive manic and depressive (with suicidal thoughts) dimensions. Further studies should be carried out to confirm these findings. |
format | Text |
id | pubmed-2311299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-23112992008-04-16 The link between neurosteroids and syndromic/syndromal components of the mood spectrum disorders in women during the premenstrual phase Hardoy, Maria Carolina Sardu, Claudia Dell'Osso, Liliana Carta, Mauro Giovanni Clin Pract Epidemiol Ment Health Research OBJECTIVES: Females with a lifetime diagnosis of major mood disorder (Bipolar Disorder BD, Major Depressive Disorder MMD) investigated during the luteal phase of their menstrual cycle and in a condition of clinical well-being showed higher blood serum concentrations of progesterone and allopregnanolone compared to healthy controls. Women with BD presented even higher levels than those affected by MDD. This study attempted to verify, in line with a dimensional approach, if the possible differences in neurohormonal levels may be directly linked to some syndromal clusters (dimensions) of the mood spectrum disorders indipendently of diagnosis. METHODS: Premenstrual concentrations of allopregnanolone, THDOC, progesterone, and cortisol were measured in 3 groups of women: 17 BD and 14 MDD outpatients, and 16 control subjects. Psychiatric evaluation was performed with the SCID-I interview and the SCI-MOODS-SR questionnaire. The correlation between steroid levels and mood disorder syndromal cluster (SCI-MOODS-SR domains and sub-domains) was evaluated by means of analysis of main components with Varimax rotation and Kaiser's normalization (which provided for inclusion of all components with an Eigen value >1). RESULTS: Analysis of the main components evidenced the presence of 3 components: 1) mania, 2) depression both with mixed component 3) steroid + manic cognitivity and suicidal ideas. CONCLUSION: Levels of allopregnanolone and progesterone do not correlate with the association of the depressive and manic syndromes, but rather with mixed symptomatological aspects, and in particular with cognitive manic and depressive (with suicidal thoughts) dimensions. Further studies should be carried out to confirm these findings. BioMed Central 2008-02-26 /pmc/articles/PMC2311299/ /pubmed/18302757 http://dx.doi.org/10.1186/1745-0179-4-3 Text en Copyright ©2008 Hardoy et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Hardoy, Maria Carolina Sardu, Claudia Dell'Osso, Liliana Carta, Mauro Giovanni The link between neurosteroids and syndromic/syndromal components of the mood spectrum disorders in women during the premenstrual phase |
title | The link between neurosteroids and syndromic/syndromal components of the mood spectrum disorders in women during the premenstrual phase |
title_full | The link between neurosteroids and syndromic/syndromal components of the mood spectrum disorders in women during the premenstrual phase |
title_fullStr | The link between neurosteroids and syndromic/syndromal components of the mood spectrum disorders in women during the premenstrual phase |
title_full_unstemmed | The link between neurosteroids and syndromic/syndromal components of the mood spectrum disorders in women during the premenstrual phase |
title_short | The link between neurosteroids and syndromic/syndromal components of the mood spectrum disorders in women during the premenstrual phase |
title_sort | link between neurosteroids and syndromic/syndromal components of the mood spectrum disorders in women during the premenstrual phase |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2311299/ https://www.ncbi.nlm.nih.gov/pubmed/18302757 http://dx.doi.org/10.1186/1745-0179-4-3 |
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