Cargando…

Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers

We have used a human artificial chromosome (HAC) to manipulate the epigenetic state of chromatin within an active kinetochore. The HAC has a dimeric α-satellite repeat containing one natural monomer with a CENP-B binding site, and one completely artificial synthetic monomer with the CENP-B box repla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakano, Megumi, Cardinale, Stefano, Noskov, Vladimir N., Gassmann, Reto, Vagnarelli, Paola, Kandels-Lewis, Stefanie, Larionov, Vladimir, Earnshaw, William C., Masumoto, Hiroshi
Formato:	Texto
Lenguaje:	English
Publicado:	Cell Press 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2311382/ https://www.ncbi.nlm.nih.gov/pubmed/18410728 http://dx.doi.org/10.1016/j.devcel.2008.02.001

Ejemplares similares

Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly
por: Ohzeki, Jun-ichirou, et al.
Publicado: (2012)

DNA content of a functioning chicken kinetochore
por: Ribeiro, Susana Abreu, et al.
Publicado: (2014)

CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly
por: Shono, Nobuaki, et al.
Publicado: (2015)

Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance
por: Molina, Oscar, et al.
Publicado: (2016)

The Centromere: Chromatin Foundation for the Kinetochore Machinery
por: Fukagawa, Tatsuo, et al.
Publicado: (2014)

KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation
por: Ohzeki, Jun-ichirou, et al.
Publicado: (2016)

Method to Assemble Genomic DNA Fragments or Genes on Human Artificial Chromosome with Regulated Kinetochore Using a Multi-Integrase System
por: Lee, Nicholas C. O., et al.
Publicado: (2017)

Actively transcribed rDNA and distal junction (DJ) sequence are involved in association of NORs with nucleoli
por: Liskovykh, Mikhail, et al.
Publicado: (2023)

Combination of CENP-B Box Positive and Negative Synthetic Alpha Satellite Repeats Improves De Novo Human Artificial Chromosome Formation
por: Okazaki, Koei, et al.
Publicado: (2022)

Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore
por: Bergmann, Jan H, et al.
Publicado: (2011)

3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin
por: Booth, Daniel G., et al.
Publicado: (2016)

CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly
por: Otake, Koichiro, et al.
Publicado: (2020)

Protecting a transgene expression from the HAC-based vector by different chromatin insulators
por: Lee, Nicholas CO, et al.
Publicado: (2013)

CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA
por: Ohzeki, Jun-ichirou, et al.
Publicado: (2002)

Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome
por: Erliandri, Indri, et al.
Publicado: (2014)

Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore
por: Prevo, Bram, et al.
Publicado: (2023)

NudE regulates dynein at kinetochores but is dispensable for other dynein functions in the C. elegans early embryo
por: Simões, Patrícia A., et al.
Publicado: (2018)

Rapid generation of long synthetic tandem repeats and its application for analysis in human artificial chromosome formation
por: Ebersole, Tom, et al.
Publicado: (2005)

Protein phosphatases in chromatin structure and function()
por: Gil, Raquel Sales, et al.
Publicado: (2019)

Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3
por: Martins, Nuno M. C., et al.
Publicado: (2016)

Mitotic post-translational modifications of histones promote chromatin compaction in vitro
por: Zhiteneva, Alisa, et al.
Publicado: (2017)

Bridgin connects the outer kinetochore to centromeric chromatin
por: Sridhar, Shreyas, et al.
Publicado: (2021)

Spindle assembly checkpoint proteins are positioned close to core microtubule attachment sites at kinetochores
por: Varma, Dileep, et al.
Publicado: (2013)

Kinetochore stretching inactivates the spindle assembly checkpoint
por: Uchida, Kazuhiko S.K., et al.
Publicado: (2009)

Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTA(VP64) expression cassette
por: Kononenko, Artem V., et al.
Publicado: (2015)

Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies
por: Pesenti, Elisa, et al.
Publicado: (2018)

Self-Assembly of the RZZ Complex into Filaments Drives Kinetochore Expansion in the Absence of Microtubule Attachment
por: Pereira, Cláudia, et al.
Publicado: (2018)

Kinetochores and chromatin diminution in early embryos of Parascaris univalens
Publicado: (1992)

Chromatin Assembly at Kinetochores Is Uncoupled from DNA Replication
por: Shelby, Richard D., et al.
Publicado: (2000)

In vitro centromere and kinetochore assembly on defined chromatin templates
por: Guse, Annika, et al.
Publicado: (2011)

Relative contributions of chromatin and kinetochores to mitotic spindle assembly
por: O'Connell, Christopher B., et al.
Publicado: (2009)

Nuclear-enriched protein phosphatase 4 ensures outer kinetochore assembly prior to nuclear dissolution
por: Rocha, Helder, et al.
Publicado: (2023)

Kinetochore inactivation by expression of a repressive mRNA
por: Chen, Jingxun, et al.
Publicado: (2017)

Rapid generation of long tandem DNA repeat arrays by homologous recombination in yeast to study their function in mammalian genomes
por: Noskov, Vladimir N, et al.
Publicado: (2011)

Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies
por: Kouprina, Natalay, et al.
Publicado: (2018)

A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function
por: Kononenko, Artem V., et al.
Publicado: (2014)

INCENP Centromere and Spindle Targeting: Identification of Essential Conserved Motifs and Involvement of Heterochromatin Protein HP1
por: Ainsztein, Alexandra M., et al.
Publicado: (1998)

Identification of a Predominant Co-Regulation among Kinetochore Genes, Prospective Regulatory Elements, and Association with Genomic Instability
por: Reinhold, William C., et al.
Publicado: (2011)

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells
por: Petrov, Nikolai, et al.
Publicado: (2021)

Nap1 regulates proper CENP-B binding to nucleosomes
por: Tachiwana, Hiroaki, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_hflo7s1pvb6aaqofhp813nu32a