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Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers

We have used a human artificial chromosome (HAC) to manipulate the epigenetic state of chromatin within an active kinetochore. The HAC has a dimeric α-satellite repeat containing one natural monomer with a CENP-B binding site, and one completely artificial synthetic monomer with the CENP-B box repla...

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Detalles Bibliográficos
Autores principales:	Nakano, Megumi, Cardinale, Stefano, Noskov, Vladimir N., Gassmann, Reto, Vagnarelli, Paola, Kandels-Lewis, Stefanie, Larionov, Vladimir, Earnshaw, William C., Masumoto, Hiroshi
Formato:	Texto
Lenguaje:	English
Publicado:	Cell Press 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2311382/ https://www.ncbi.nlm.nih.gov/pubmed/18410728 http://dx.doi.org/10.1016/j.devcel.2008.02.001

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