Cargando…
Channel Openings Are Necessary but not Sufficient for Use-dependent Block of Cardiac Na(+) Channels by Flecainide: Evidence from the Analysis of Disease-linked Mutations
Na(+) channel blockers such as flecainide have found renewed usefulness in the diagnosis and treatment of two clinical syndromes arising from inherited mutations in SCN5A, the gene encoding the α subunit of the cardiac voltage–gated Na(+) channel. The Brugada syndrome (BrS) and the LQT-3 variant of...
| Autores principales: | , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2002
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2311398/ https://www.ncbi.nlm.nih.gov/pubmed/12084774 http://dx.doi.org/10.1085/jgp.20028558 |