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Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals

BACKGROUND: To determine whether acute (single dose) and/or chronic (14-days) supplementation of CoQ10 will improve anaerobic and/or aerobic exercise performance by increasing plasma and muscle CoQ10 concentrations within trained and untrained individuals. METHODS: Twenty-two aerobically trained and...

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Autores principales: Cooke, Matthew, Iosia, Mike, Buford, Thomas, Shelmadine, Brian, Hudson, Geoffrey, Kerksick, Chad, Rasmussen, Christopher, Greenwood, Mike, Leutholtz, Brian, Willoughby, Darryn, Kreider, Richard
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315638/
https://www.ncbi.nlm.nih.gov/pubmed/18318910
http://dx.doi.org/10.1186/1550-2783-5-8
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author Cooke, Matthew
Iosia, Mike
Buford, Thomas
Shelmadine, Brian
Hudson, Geoffrey
Kerksick, Chad
Rasmussen, Christopher
Greenwood, Mike
Leutholtz, Brian
Willoughby, Darryn
Kreider, Richard
author_facet Cooke, Matthew
Iosia, Mike
Buford, Thomas
Shelmadine, Brian
Hudson, Geoffrey
Kerksick, Chad
Rasmussen, Christopher
Greenwood, Mike
Leutholtz, Brian
Willoughby, Darryn
Kreider, Richard
author_sort Cooke, Matthew
collection PubMed
description BACKGROUND: To determine whether acute (single dose) and/or chronic (14-days) supplementation of CoQ10 will improve anaerobic and/or aerobic exercise performance by increasing plasma and muscle CoQ10 concentrations within trained and untrained individuals. METHODS: Twenty-two aerobically trained and nineteen untrained male and female subjects (26.1 ± 7.6 yrs, 172 ± 8.7 cm, 73.5 ± 17 kg, and 21.2 ± 7.0%) were randomized to ingest in a double-blind manner either 100 mg of a dextrose placebo (CON) or a fast-melt CoQ10 supplement (CoQ10) twice a day for 14-days. On the first day of supplementation, subjects donated fasting blood samples and a muscle biopsy. Subjects were then given 200 mg of the placebo or the CoQ10 supplement. Sixty minutes following supplement ingestion, subjects completed an isokinetic knee extension endurance test, a 30-second wingate anaerobic capacity test, and a maximal cardiopulmonary graded exercise test interspersed with 30-minutes of recovery. Additional blood samples were taken immediately following each exercise test and a second muscle biopsy sample was taken following the final exercise test. Subjects consumed twice daily (morning and night), 100 mg of either supplement for a period of 14-days, and then returned to the lab to complete the same battery of tests. Data was analyzed using repeated measures ANOVA with an alpha of 0.05. RESULTS: Plasma CoQ10 levels were significantly increased following 2 weeks of CoQ10 supplementation (p < 0.001); while a trend for higher muscle CoQ10 levels was observed after acute CoQ10 ingestion (p = 0.098). A trend for lower serum superoxide dismutase (SOD) was observed following acute supplementation with CoQ10 (p = 0.06), whereas serum malondialdehyde (MDA) tended to be significantly higher (p < 0.05). Following acute ingestion of CoQ10, plasma CoQ10 levels were significantly correlated to muscle CoQ10 levels; maximal oxygen consumption; and treadmill time to exhaustion. A trend for increased time to exhaustion was observed following 2 weeks of CoQ10 supplementation (p = 0.06). CONCLUSION: Acute supplementation with CoQ10 resulted in higher muscle CoQ10 concentration, lower serum SOD oxidative stress, and higher MDA levels during and following exercise. Chronic CoQ10 supplementation increased plasma CoQ10 concentrations and tended to increase time to exhaustion. Results indicate that acute and chronic supplementation of CoQ10 may affect acute and/or chronic responses to various types of exercise.
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spelling pubmed-23156382008-04-17 Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals Cooke, Matthew Iosia, Mike Buford, Thomas Shelmadine, Brian Hudson, Geoffrey Kerksick, Chad Rasmussen, Christopher Greenwood, Mike Leutholtz, Brian Willoughby, Darryn Kreider, Richard J Int Soc Sports Nutr Research Article BACKGROUND: To determine whether acute (single dose) and/or chronic (14-days) supplementation of CoQ10 will improve anaerobic and/or aerobic exercise performance by increasing plasma and muscle CoQ10 concentrations within trained and untrained individuals. METHODS: Twenty-two aerobically trained and nineteen untrained male and female subjects (26.1 ± 7.6 yrs, 172 ± 8.7 cm, 73.5 ± 17 kg, and 21.2 ± 7.0%) were randomized to ingest in a double-blind manner either 100 mg of a dextrose placebo (CON) or a fast-melt CoQ10 supplement (CoQ10) twice a day for 14-days. On the first day of supplementation, subjects donated fasting blood samples and a muscle biopsy. Subjects were then given 200 mg of the placebo or the CoQ10 supplement. Sixty minutes following supplement ingestion, subjects completed an isokinetic knee extension endurance test, a 30-second wingate anaerobic capacity test, and a maximal cardiopulmonary graded exercise test interspersed with 30-minutes of recovery. Additional blood samples were taken immediately following each exercise test and a second muscle biopsy sample was taken following the final exercise test. Subjects consumed twice daily (morning and night), 100 mg of either supplement for a period of 14-days, and then returned to the lab to complete the same battery of tests. Data was analyzed using repeated measures ANOVA with an alpha of 0.05. RESULTS: Plasma CoQ10 levels were significantly increased following 2 weeks of CoQ10 supplementation (p < 0.001); while a trend for higher muscle CoQ10 levels was observed after acute CoQ10 ingestion (p = 0.098). A trend for lower serum superoxide dismutase (SOD) was observed following acute supplementation with CoQ10 (p = 0.06), whereas serum malondialdehyde (MDA) tended to be significantly higher (p < 0.05). Following acute ingestion of CoQ10, plasma CoQ10 levels were significantly correlated to muscle CoQ10 levels; maximal oxygen consumption; and treadmill time to exhaustion. A trend for increased time to exhaustion was observed following 2 weeks of CoQ10 supplementation (p = 0.06). CONCLUSION: Acute supplementation with CoQ10 resulted in higher muscle CoQ10 concentration, lower serum SOD oxidative stress, and higher MDA levels during and following exercise. Chronic CoQ10 supplementation increased plasma CoQ10 concentrations and tended to increase time to exhaustion. Results indicate that acute and chronic supplementation of CoQ10 may affect acute and/or chronic responses to various types of exercise. BioMed Central 2008-03-04 /pmc/articles/PMC2315638/ /pubmed/18318910 http://dx.doi.org/10.1186/1550-2783-5-8 Text en Copyright © 2008 Cooke et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cooke, Matthew
Iosia, Mike
Buford, Thomas
Shelmadine, Brian
Hudson, Geoffrey
Kerksick, Chad
Rasmussen, Christopher
Greenwood, Mike
Leutholtz, Brian
Willoughby, Darryn
Kreider, Richard
Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals
title Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals
title_full Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals
title_fullStr Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals
title_full_unstemmed Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals
title_short Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals
title_sort effects of acute and 14-day coenzyme q10 supplementation on exercise performance in both trained and untrained individuals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315638/
https://www.ncbi.nlm.nih.gov/pubmed/18318910
http://dx.doi.org/10.1186/1550-2783-5-8
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