Spinophilin and the immune synapse

Extensive alterations in cellular organization are known to accompany the responses of sensitized T cells to target cells presenting an antigen of interest. Now, equally if not more dramatic changes are found to take place in cells presenting an antigen. With the help of a spinophilin-GFP fusion pro...

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Detalles Bibliográficos
Autores principales: Seed, Brian, Xavier, Ramnik
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315665/
https://www.ncbi.nlm.nih.gov/pubmed/18411314
http://dx.doi.org/10.1083/jcb.200803120
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author Seed, Brian
Xavier, Ramnik
author_facet Seed, Brian
Xavier, Ramnik
author_sort Seed, Brian
collection PubMed
description Extensive alterations in cellular organization are known to accompany the responses of sensitized T cells to target cells presenting an antigen of interest. Now, equally if not more dramatic changes are found to take place in cells presenting an antigen. With the help of a spinophilin-GFP fusion protein, Bloom et al. (Bloom, O., J.J. Unternaehrer, A. Jiang, J.-S. Shin, L. Delamarre, P. Allen, and I. Mellman. 2008. J. Cell Biol. 181:203–211) have captured a remarkable polarization of the cellular architecture of dendritic cells presenting an antigen to T cells.
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spelling pubmed-23156652008-10-21 Spinophilin and the immune synapse Seed, Brian Xavier, Ramnik J Cell Biol Reviews Extensive alterations in cellular organization are known to accompany the responses of sensitized T cells to target cells presenting an antigen of interest. Now, equally if not more dramatic changes are found to take place in cells presenting an antigen. With the help of a spinophilin-GFP fusion protein, Bloom et al. (Bloom, O., J.J. Unternaehrer, A. Jiang, J.-S. Shin, L. Delamarre, P. Allen, and I. Mellman. 2008. J. Cell Biol. 181:203–211) have captured a remarkable polarization of the cellular architecture of dendritic cells presenting an antigen to T cells. The Rockefeller University Press 2008-04-21 /pmc/articles/PMC2315665/ /pubmed/18411314 http://dx.doi.org/10.1083/jcb.200803120 Text en Copyright © 2008, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Seed, Brian
Xavier, Ramnik
Spinophilin and the immune synapse
title Spinophilin and the immune synapse
title_full Spinophilin and the immune synapse
title_fullStr Spinophilin and the immune synapse
title_full_unstemmed Spinophilin and the immune synapse
title_short Spinophilin and the immune synapse
title_sort spinophilin and the immune synapse
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315665/
https://www.ncbi.nlm.nih.gov/pubmed/18411314
http://dx.doi.org/10.1083/jcb.200803120
work_keys_str_mv AT seedbrian spinophilinandtheimmunesynapse
AT xavierramnik spinophilinandtheimmunesynapse

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