Decoding ARE-mediated decay: is microRNA part of the equation?

Messenger ribonucleic acids (mRNAs) containing adenine/uridine-rich elements (AREs) in their 3′ untranslated region are particularly labile, allowing for the regulation of expression for growth factors, oncoproteins, and cytokines. The regulators, effectors, and location of ARE-mediated decay (AMD)...

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Detalles Bibliográficos
Autores principales: von Roretz, Christopher, Gallouzi, Imed-Eddine
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315667/
https://www.ncbi.nlm.nih.gov/pubmed/18411313
http://dx.doi.org/10.1083/jcb.200712054
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author von Roretz, Christopher
Gallouzi, Imed-Eddine
author_facet von Roretz, Christopher
Gallouzi, Imed-Eddine
author_sort von Roretz, Christopher
collection PubMed
description Messenger ribonucleic acids (mRNAs) containing adenine/uridine-rich elements (AREs) in their 3′ untranslated region are particularly labile, allowing for the regulation of expression for growth factors, oncoproteins, and cytokines. The regulators, effectors, and location of ARE-mediated decay (AMD) have been investigated by many groups in recent years, and several links have been found between AMD and microRNA-mediated decay. We highlight these similarities, along with recent advances in the field of AMD, and also mention how there is still much left unknown surrounding this specialized mode of mRNA decay.
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spelling pubmed-23156672008-10-21 Decoding ARE-mediated decay: is microRNA part of the equation? von Roretz, Christopher Gallouzi, Imed-Eddine J Cell Biol Reviews Messenger ribonucleic acids (mRNAs) containing adenine/uridine-rich elements (AREs) in their 3′ untranslated region are particularly labile, allowing for the regulation of expression for growth factors, oncoproteins, and cytokines. The regulators, effectors, and location of ARE-mediated decay (AMD) have been investigated by many groups in recent years, and several links have been found between AMD and microRNA-mediated decay. We highlight these similarities, along with recent advances in the field of AMD, and also mention how there is still much left unknown surrounding this specialized mode of mRNA decay. The Rockefeller University Press 2008-04-21 /pmc/articles/PMC2315667/ /pubmed/18411313 http://dx.doi.org/10.1083/jcb.200712054 Text en Copyright © 2008, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
von Roretz, Christopher
Gallouzi, Imed-Eddine
Decoding ARE-mediated decay: is microRNA part of the equation?
title Decoding ARE-mediated decay: is microRNA part of the equation?
title_full Decoding ARE-mediated decay: is microRNA part of the equation?
title_fullStr Decoding ARE-mediated decay: is microRNA part of the equation?
title_full_unstemmed Decoding ARE-mediated decay: is microRNA part of the equation?
title_short Decoding ARE-mediated decay: is microRNA part of the equation?
title_sort decoding are-mediated decay: is microrna part of the equation?
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315667/
https://www.ncbi.nlm.nih.gov/pubmed/18411313
http://dx.doi.org/10.1083/jcb.200712054
work_keys_str_mv AT vonroretzchristopher decodingaremediateddecayismicrornapartoftheequation
AT gallouziimededdine decodingaremediateddecayismicrornapartoftheequation

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