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Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin

The MRE11–RAD50–Nijmegen breakage syndrome 1 (NBS1 [MRN]) complex accumulates at sites of DNA double-strand breaks (DSBs) in microscopically discernible nuclear foci. Focus formation by the MRN complex is dependent on MDC1, a large nuclear protein that directly interacts with phosphorylated H2AX. In...

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Detalles Bibliográficos
Autores principales:	Spycher, Christoph, Miller, Edward S., Townsend, Kelly, Pavic, Lucijana, Morrice, Nicholas A., Janscak, Pavel, Stewart, Grant S., Stucki, Manuel
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315671/ https://www.ncbi.nlm.nih.gov/pubmed/18411308 http://dx.doi.org/10.1083/jcb.200709008

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