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DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement

Dynamic turnover of the spindle is a driving force for chromosome congression and segregation in mitosis. Through a functional genomic analysis, we identify DDA3 as a previously unknown regulator of spindle dynamics that is essential for mitotic progression. DDA3 depletion results in a high frequenc...

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Detalles Bibliográficos
Autores principales:	Jang, Chang-Young, Wong, Jim, Coppinger, Judith A., Seki, Akiko, Yates, John R., Fang, Guowei
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315673/ https://www.ncbi.nlm.nih.gov/pubmed/18411309 http://dx.doi.org/10.1083/jcb.200711032

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