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Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway

The chemotherapeutic agent cisplatin is widely used in treatment of solid tumors. In breast cancer cells, cisplatin produces early and marked changes in cell morphology and the actin cytoskeleton. These changes manifest as loss of lamellipodia/filopodia and appearance of membrane ruffles. Furthermor...

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Detalles Bibliográficos
Autores principales:	Zeidan, Youssef H., Jenkins, Russell W., Hannun, Yusuf A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315679/ https://www.ncbi.nlm.nih.gov/pubmed/18426979 http://dx.doi.org/10.1083/jcb.200705060

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