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A novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis

Glucocorticoid excess increases fat mass, preferentially within omental depots; yet circulating cortisol concentrations are normal in most patients with metabolic syndrome (MS). At a pre-receptor level, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activates cortisol from cortisone locally with...

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Detalles Bibliográficos
Autores principales:	Bujalska, I J, Gathercole, L L, Tomlinson, J W, Darimont, C, Ermolieff, J, Fanjul, A N, Rejto, P A, Stewart, P M
Formato:	Texto
Lenguaje:	English
Publicado:	BioScientifica 2008
Materias:	Regular papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315694/ https://www.ncbi.nlm.nih.gov/pubmed/18434359 http://dx.doi.org/10.1677/JOE-08-0050

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