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Translational control by cytoplasmic polyadenylation in Xenopus oocytes

Elongation of the poly(A) tails of specific mRNAs in the cytoplasm is a crucial regulatory step in oogenesis and early development of many animal species. The best studied example is the regulation of translation by cytoplasmic polyadenylation elements (CPEs) in the 3′ untranslated region of mRNAs i...

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Detalles Bibliográficos
Autores principales: Radford, Helois E., Meijer, Hedda A., de Moor, Cornelia H.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323027/
https://www.ncbi.nlm.nih.gov/pubmed/18316045
http://dx.doi.org/10.1016/j.bbagrm.2008.02.002
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author Radford, Helois E.
Meijer, Hedda A.
de Moor, Cornelia H.
author_facet Radford, Helois E.
Meijer, Hedda A.
de Moor, Cornelia H.
author_sort Radford, Helois E.
collection PubMed
description Elongation of the poly(A) tails of specific mRNAs in the cytoplasm is a crucial regulatory step in oogenesis and early development of many animal species. The best studied example is the regulation of translation by cytoplasmic polyadenylation elements (CPEs) in the 3′ untranslated region of mRNAs involved in Xenopus oocyte maturation. In this review we discuss the mechanism of translational control by the CPE binding protein (CPEB) in Xenopus 1. The cytoplasmic polyadenylation machinery such as CPEB, the subunits of cleavage and polyadenylation specificity factor (CPSF), symplekin, Gld-2 and poly(A) polymerase (PAP). 2. The signal transduction that leads to the activation of CPE-mediated polyadenylation during oocyte maturation, including the potential roles of kinases such as MAPK, Aurora A, CamKII, cdk1/Ringo and cdk1/cyclin B. 3. The role of deadenylation and translational repression, including the potential involvement of PARN, CCR4/NOT, maskin, pumilio, Xp54 (Ddx6, Rck), other P-body components and isoforms of the cap binding initiation factor eIF4E. Finally we discuss some of the remaining questions regarding the mechanisms of translational regulation by cytoplasmic polyadenylation and give our view on where our knowledge is likely to be expanded in the near future.
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spelling pubmed-23230272008-05-09 Translational control by cytoplasmic polyadenylation in Xenopus oocytes Radford, Helois E. Meijer, Hedda A. de Moor, Cornelia H. Biochim Biophys Acta Review Elongation of the poly(A) tails of specific mRNAs in the cytoplasm is a crucial regulatory step in oogenesis and early development of many animal species. The best studied example is the regulation of translation by cytoplasmic polyadenylation elements (CPEs) in the 3′ untranslated region of mRNAs involved in Xenopus oocyte maturation. In this review we discuss the mechanism of translational control by the CPE binding protein (CPEB) in Xenopus 1. The cytoplasmic polyadenylation machinery such as CPEB, the subunits of cleavage and polyadenylation specificity factor (CPSF), symplekin, Gld-2 and poly(A) polymerase (PAP). 2. The signal transduction that leads to the activation of CPE-mediated polyadenylation during oocyte maturation, including the potential roles of kinases such as MAPK, Aurora A, CamKII, cdk1/Ringo and cdk1/cyclin B. 3. The role of deadenylation and translational repression, including the potential involvement of PARN, CCR4/NOT, maskin, pumilio, Xp54 (Ddx6, Rck), other P-body components and isoforms of the cap binding initiation factor eIF4E. Finally we discuss some of the remaining questions regarding the mechanisms of translational regulation by cytoplasmic polyadenylation and give our view on where our knowledge is likely to be expanded in the near future. Elsevier Pub. Co 2008-04 /pmc/articles/PMC2323027/ /pubmed/18316045 http://dx.doi.org/10.1016/j.bbagrm.2008.02.002 Text en © 2008 Elsevier B.V. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Review
Radford, Helois E.
Meijer, Hedda A.
de Moor, Cornelia H.
Translational control by cytoplasmic polyadenylation in Xenopus oocytes
title Translational control by cytoplasmic polyadenylation in Xenopus oocytes
title_full Translational control by cytoplasmic polyadenylation in Xenopus oocytes
title_fullStr Translational control by cytoplasmic polyadenylation in Xenopus oocytes
title_full_unstemmed Translational control by cytoplasmic polyadenylation in Xenopus oocytes
title_short Translational control by cytoplasmic polyadenylation in Xenopus oocytes
title_sort translational control by cytoplasmic polyadenylation in xenopus oocytes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323027/
https://www.ncbi.nlm.nih.gov/pubmed/18316045
http://dx.doi.org/10.1016/j.bbagrm.2008.02.002
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