Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance

BACKGROUND: Insulin and insulin-like growth factors (IGFs) signal through a highly conserved pathway and control growth and metabolism in both vertebrates and invertebrates. In mammals, insulin-like growth factor binding proteins (IGFBPs) bind IGFs with high affinity and modulate their mitogenic, an...

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Detalles Bibliográficos
Autores principales: Honegger, Basil, Galic, Milos, Köhler, Katja, Wittwer, Franz, Brogiolo, Walter, Hafen, Ernst, Stocker, Hugo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323038/
https://www.ncbi.nlm.nih.gov/pubmed/18412985
http://dx.doi.org/10.1186/jbiol72

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