Cargando…
Evolutionary conservation of regulated longevity assurance mechanisms
BACKGROUND: To what extent are the determinants of aging in animal species universal? Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) is an evolutionarily conserved (public) regulator of longevity; yet it remains unclear whether the genes and biochemical processes through which IIS acts o...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323215/ https://www.ncbi.nlm.nih.gov/pubmed/17612391 http://dx.doi.org/10.1186/gb-2007-8-7-r132 |
_version_ | 1782152624913514496 |
---|---|
author | McElwee, Joshua J Schuster, Eugene Blanc, Eric Piper, Matthew D Thomas, James H Patel, Dhaval S Selman, Colin Withers, Dominic J Thornton, Janet M Partridge, Linda Gems, David |
author_facet | McElwee, Joshua J Schuster, Eugene Blanc, Eric Piper, Matthew D Thomas, James H Patel, Dhaval S Selman, Colin Withers, Dominic J Thornton, Janet M Partridge, Linda Gems, David |
author_sort | McElwee, Joshua J |
collection | PubMed |
description | BACKGROUND: To what extent are the determinants of aging in animal species universal? Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) is an evolutionarily conserved (public) regulator of longevity; yet it remains unclear whether the genes and biochemical processes through which IIS acts on aging are public or private (that is, lineage specific). To address this, we have applied a novel, multi-level cross-species comparative analysis to compare gene expression changes accompanying increased longevity in mutant nematodes, fruitflies and mice with reduced IIS. RESULTS: Surprisingly, there is little evolutionary conservation at the level of individual, orthologous genes or paralogous genes under IIS regulation. However, a number of gene categories are significantly enriched for genes whose expression changes in long-lived animals of all three species. Down-regulated categories include protein biosynthesis-associated genes. Up-regulated categories include sugar catabolism, energy generation, glutathione-S-transferases (GSTs) and several other categories linked to cellular detoxification (that is, phase 1 and phase 2 metabolism of xenobiotic and endobiotic toxins). Protein biosynthesis and GST activity have recently been linked to aging and longevity assurance, respectively. CONCLUSION: These processes represent candidate, regulated mechanisms of longevity-control that are conserved across animal species. The longevity assurance mechanisms via which IIS acts appear to be lineage-specific at the gene level (private), but conserved at the process level (or semi-public). In the case of GSTs, and cellular detoxification generally, this suggests that the mechanisms of aging against which longevity assurance mechanisms act are, to some extent, lineage specific. |
format | Text |
id | pubmed-2323215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-23232152008-04-19 Evolutionary conservation of regulated longevity assurance mechanisms McElwee, Joshua J Schuster, Eugene Blanc, Eric Piper, Matthew D Thomas, James H Patel, Dhaval S Selman, Colin Withers, Dominic J Thornton, Janet M Partridge, Linda Gems, David Genome Biol Research BACKGROUND: To what extent are the determinants of aging in animal species universal? Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) is an evolutionarily conserved (public) regulator of longevity; yet it remains unclear whether the genes and biochemical processes through which IIS acts on aging are public or private (that is, lineage specific). To address this, we have applied a novel, multi-level cross-species comparative analysis to compare gene expression changes accompanying increased longevity in mutant nematodes, fruitflies and mice with reduced IIS. RESULTS: Surprisingly, there is little evolutionary conservation at the level of individual, orthologous genes or paralogous genes under IIS regulation. However, a number of gene categories are significantly enriched for genes whose expression changes in long-lived animals of all three species. Down-regulated categories include protein biosynthesis-associated genes. Up-regulated categories include sugar catabolism, energy generation, glutathione-S-transferases (GSTs) and several other categories linked to cellular detoxification (that is, phase 1 and phase 2 metabolism of xenobiotic and endobiotic toxins). Protein biosynthesis and GST activity have recently been linked to aging and longevity assurance, respectively. CONCLUSION: These processes represent candidate, regulated mechanisms of longevity-control that are conserved across animal species. The longevity assurance mechanisms via which IIS acts appear to be lineage-specific at the gene level (private), but conserved at the process level (or semi-public). In the case of GSTs, and cellular detoxification generally, this suggests that the mechanisms of aging against which longevity assurance mechanisms act are, to some extent, lineage specific. BioMed Central 2007 2007-07-05 /pmc/articles/PMC2323215/ /pubmed/17612391 http://dx.doi.org/10.1186/gb-2007-8-7-r132 Text en Copyright © 2007 McElwee et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research McElwee, Joshua J Schuster, Eugene Blanc, Eric Piper, Matthew D Thomas, James H Patel, Dhaval S Selman, Colin Withers, Dominic J Thornton, Janet M Partridge, Linda Gems, David Evolutionary conservation of regulated longevity assurance mechanisms |
title | Evolutionary conservation of regulated longevity assurance mechanisms |
title_full | Evolutionary conservation of regulated longevity assurance mechanisms |
title_fullStr | Evolutionary conservation of regulated longevity assurance mechanisms |
title_full_unstemmed | Evolutionary conservation of regulated longevity assurance mechanisms |
title_short | Evolutionary conservation of regulated longevity assurance mechanisms |
title_sort | evolutionary conservation of regulated longevity assurance mechanisms |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323215/ https://www.ncbi.nlm.nih.gov/pubmed/17612391 http://dx.doi.org/10.1186/gb-2007-8-7-r132 |
work_keys_str_mv | AT mcelweejoshuaj evolutionaryconservationofregulatedlongevityassurancemechanisms AT schustereugene evolutionaryconservationofregulatedlongevityassurancemechanisms AT blanceric evolutionaryconservationofregulatedlongevityassurancemechanisms AT pipermatthewd evolutionaryconservationofregulatedlongevityassurancemechanisms AT thomasjamesh evolutionaryconservationofregulatedlongevityassurancemechanisms AT pateldhavals evolutionaryconservationofregulatedlongevityassurancemechanisms AT selmancolin evolutionaryconservationofregulatedlongevityassurancemechanisms AT withersdominicj evolutionaryconservationofregulatedlongevityassurancemechanisms AT thorntonjanetm evolutionaryconservationofregulatedlongevityassurancemechanisms AT partridgelinda evolutionaryconservationofregulatedlongevityassurancemechanisms AT gemsdavid evolutionaryconservationofregulatedlongevityassurancemechanisms |