Novel metrics for evaluating the functional coherence of protein groups via protein semantic network

We present the metrics for assessing overall functional coherence of a group of proteins based on associated biomedical literature. A probabilistic topic model is applied to extract biologic concepts from a corpus of protein-related biomedical literature. Bipartite protein semantic networks are cons...

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Detalles Bibliográficos
Autores principales: Zheng, Bin, Lu, Xinghua
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323239/
https://www.ncbi.nlm.nih.gov/pubmed/17672896
http://dx.doi.org/10.1186/gb-2007-8-7-r153
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author Zheng, Bin
Lu, Xinghua
author_facet Zheng, Bin
Lu, Xinghua
author_sort Zheng, Bin
collection PubMed
description We present the metrics for assessing overall functional coherence of a group of proteins based on associated biomedical literature. A probabilistic topic model is applied to extract biologic concepts from a corpus of protein-related biomedical literature. Bipartite protein semantic networks are constructed, so that the functional coherence of a protein group can be evaluated with metrics that measure the closeness and strength of connectivity of the proteins in the network.
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spelling pubmed-23232392008-04-21 Novel metrics for evaluating the functional coherence of protein groups via protein semantic network Zheng, Bin Lu, Xinghua Genome Biol Method We present the metrics for assessing overall functional coherence of a group of proteins based on associated biomedical literature. A probabilistic topic model is applied to extract biologic concepts from a corpus of protein-related biomedical literature. Bipartite protein semantic networks are constructed, so that the functional coherence of a protein group can be evaluated with metrics that measure the closeness and strength of connectivity of the proteins in the network. BioMed Central 2007 2007-07-31 /pmc/articles/PMC2323239/ /pubmed/17672896 http://dx.doi.org/10.1186/gb-2007-8-7-r153 Text en Copyright © 2007 Zheng and Lu; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Method
Zheng, Bin
Lu, Xinghua
Novel metrics for evaluating the functional coherence of protein groups via protein semantic network
title Novel metrics for evaluating the functional coherence of protein groups via protein semantic network
title_full Novel metrics for evaluating the functional coherence of protein groups via protein semantic network
title_fullStr Novel metrics for evaluating the functional coherence of protein groups via protein semantic network
title_full_unstemmed Novel metrics for evaluating the functional coherence of protein groups via protein semantic network
title_short Novel metrics for evaluating the functional coherence of protein groups via protein semantic network
title_sort novel metrics for evaluating the functional coherence of protein groups via protein semantic network
topic Method
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323239/
https://www.ncbi.nlm.nih.gov/pubmed/17672896
http://dx.doi.org/10.1186/gb-2007-8-7-r153
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AT luxinghua novelmetricsforevaluatingthefunctionalcoherenceofproteingroupsviaproteinsemanticnetwork

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