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Vaccination and Timing Influence SIV Immune Escape Viral Dynamics In Vivo
CD8+ cytotoxic T lymphocytes (CTL) can be effective at controlling HIV-1 in humans and SIV in macaques, but their utility is partly offset by mutational escape. The kinetics of CTL escape and reversion of escape mutant viruses upon transmission to MHC-mismatched hosts can help us understand CTL-medi...
Autores principales: | Loh, Liyen, Petravic, Janka, Batten, C. Jane, Davenport, Miles P, Kent, Stephen J |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323283/ https://www.ncbi.nlm.nih.gov/pubmed/18225952 http://dx.doi.org/10.1371/journal.ppat.0040012 |
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