Cargando…

dAtaxin-2 Mediates Expanded Ataxin-1-Induced Neurodegeneration in a Drosophila Model of SCA1

Spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of neurodegenerative disorders sharing atrophy of the cerebellum as a common feature. SCA1 and SCA2 are two ataxias caused by expansion of polyglutamine tracts in Ataxin-1 (ATXN1) and Ataxin-2 (ATXN2), respectively, two proteins th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Ramahi, Ismael, Pérez, Alma M, Lim, Janghoo, Zhang, Minghang, Sorensen, Rie, de Haro, Maria, Branco, Joana, Pulst, Stefan M, Zoghbi, Huda Y, Botas, Juan
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323314/ https://www.ncbi.nlm.nih.gov/pubmed/18166084 http://dx.doi.org/10.1371/journal.pgen.0030234

Ejemplares similares

Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1
por: Lee, Won-Seok, et al.
Publicado: (2022)

A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1
por: Lasagna-Reeves, Cristian A, et al.
Publicado: (2015)

Ataxin-2 Regulates RGS8 Translation in a New BAC-SCA2 Transgenic Mouse Model
por: Dansithong, Warunee, et al.
Publicado: (2015)

FOX-2 Dependent Splicing of Ataxin-2 Transcript Is Affected by Ataxin-1 Overexpression
por: Welzel, Franziska, et al.
Publicado: (2012)

Ataxin-3, DNA Damage Repair, and SCA3 Cerebellar Degeneration: On the Path to Parsimony?
por: Ward, Jacqueline M., et al.
Publicado: (2015)

Genome-Wide Screen for Modifiers of Ataxin-3 Neurodegeneration in Drosophila
por: Bilen, Julide, et al.
Publicado: (2007)

Partial Loss of Ataxin-1 Function Contributes to Transcriptional Dysregulation in Spinocerebellar Ataxia Type 1 Pathogenesis
por: Crespo-Barreto, Juan, et al.
Publicado: (2010)

Glutamine-Expanded Ataxin-7 Alters TFTC/STAGA Recruitment and Chromatin Structure Leading to Photoreceptor Dysfunction
por: Helmlinger, Dominique, et al.
Publicado: (2006)

Dissociated Fear and Spatial Learning in Mice with Deficiency of Ataxin-2
por: Huynh, Duong P., et al.
Publicado: (2009)

14-3-3 Binding to Ataxin-1(ATXN1) Regulates Its Dephosphorylation at Ser-776 and Transport to the Nucleus
por: Lai, Shaojuan, et al.
Publicado: (2011)

Polyglutamine-expanded ataxin3 alter specific gene expressions through changing DNA methylation status in SCA3/MJD
por: Ding, Dongxue, et al.
Publicado: (2020)

Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA3
por: Jung, Joonil, et al.
Publicado: (2009)

Aurora B-dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis
por: Tian, Jie, et al.
Publicado: (2015)

Universal RNAi Triggers for the Specific Inhibition of Mutant Huntingtin, Atrophin-1, Ataxin-3, and Ataxin-7 Expression
por: Kotowska-Zimmer, Anna, et al.
Publicado: (2019)

Stabilization and Degradation Mechanisms of Cytoplasmic Ataxin-1
por: Kohiyama, Mayumi F., et al.
Publicado: (2016)

PINK1 and Ataxin-2 as modifiers of growth
por: Sen, Nesli E., et al.
Publicado: (2017)

Epigenetic control of ataxin‐1 in multiple sclerosis
por: Ma, Qin, et al.
Publicado: (2022)

Design of RNAi Hairpins for Mutation-Specific Silencing of Ataxin-7 and Correction of a SCA7 Phenotype
por: Scholefield, Janine, et al.
Publicado: (2009)

A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1
por: Leysen, Seppe, et al.
Publicado: (2021)

Ataxin1L Is a Regulator of HSC Function Highlighting the Utility of Cross-Tissue Comparisons for Gene Discovery
por: Kahle, Juliette J., et al.
Publicado: (2013)

SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models
por: Marinello, Martina, et al.
Publicado: (2019)

Allele-specific targeting of mutant ataxin-3 by antisense oligonucleotides in SCA3-iPSC-derived neurons
por: Hauser, Stefan, et al.
Publicado: (2021)

Intercellular Propagation and Aggregate Seeding of Mutant Ataxin-1
por: Huang, Haoyang, et al.
Publicado: (2021)

Nucleocytoplasmic Shuttling Activity of Ataxin-3
por: Macedo-Ribeiro, Sandra, et al.
Publicado: (2009)

PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study
por: Gonsior, Kathrin, et al.
Publicado: (2020)

p62/Sequestosome 1 Regulates Aggresome Formation of Pathogenic Ataxin-3 with Expanded Polyglutamine
por: Zhou, Liang, et al.
Publicado: (2014)

Dynamics of a Protein Interaction Network Associated to the Aggregation of polyQ-Expanded Ataxin-1
por: Vagiona, Aimilia-Christina, et al.
Publicado: (2020)

Differential Degradation of Full-length and Cleaved Ataxin-7 Fragments in a Novel Stable Inducible SCA7 Model
por: Yu, Xin, et al.
Publicado: (2012)

Impaired interactions of ataxin-3 with protein complexes reveals their specific structure and functions in SCA3 Ki150 model
por: Piasecki, Piotr, et al.
Publicado: (2023)

2169: Hydrogen bonding and water accessibility changes upon expansion of PolyQ tracts in ataxin-2 and ataxin-3
por: Wen, Jingran, et al.
Publicado: (2018)

Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1
por: Ni, Chun-Lun, et al.
Publicado: (2016)

Ataxin-3 promotes genome integrity by stabilizing Chk1
por: Tu, Yingfeng, et al.
Publicado: (2017)

Conformational Behavior and Aggregation of Ataxin-3 in SDS
por: Saunders, Helen M., et al.
Publicado: (2013)

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1
por: Parfitt, David A., et al.
Publicado: (2009)

Inhibiting Expression of Mutant Huntingtin and Ataxin-3 by Targeting Expanded CAG Repeat RNAs
por: Hu, Jiaxin, et al.
Publicado: (2009)

Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes
por: Lasagna-Reeves, Cristian A, et al.
Publicado: (2015)

Ataxin-1 Fusion Partners Alter PolyQ Lethality and Aggregation
por: Rich, Tina, et al.
Publicado: (2007)

Identification of Human Proteins That Modify Misfolding and Proteotoxicity of Pathogenic Ataxin-1
por: Petrakis, Spyros, et al.
Publicado: (2012)

RNAi prevents and reverses phenotypes induced by mutant human ataxin‐1
por: Keiser, Megan S., et al.
Publicado: (2016)

Ataxin-1 regulates epithelial–mesenchymal transition of cervical cancer cells
por: Kang, A-Ram, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ruoh2o5an8umncovmft7mvuj9l