Argonaute2 Is Essential for Mammalian Gastrulation and Proper Mesoderm Formation

Mammalian Argonaute proteins (EIF2C1−4) play an essential role in RNA-induced silencing. Here, we show that the loss of eIF2C2 (Argonaute2 or Ago2) results in gastrulation arrest, ectopic expression of Brachyury (T), and mesoderm expansion. We identify a genetic interaction between Ago2 and T, as Ag...

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Detalles Bibliográficos
Autores principales: Alisch, Reid S, Jin, Peng, Epstein, Michael, Caspary, Tamara, Warren, Stephen T
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323323/
https://www.ncbi.nlm.nih.gov/pubmed/18166081
http://dx.doi.org/10.1371/journal.pgen.0030227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323323/
https://www.ncbi.nlm.nih.gov/pubmed/18166081
http://dx.doi.org/10.1371/journal.pgen.0030227

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