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Downregulation of Histone H3 Lysine 9 Methyltransferase G9a Induces Centrosome Disruption and Chromosome Instability in Cancer Cells

BACKGROUND: Modifications of the histone amino-terminal tails affect access of regulatory factors and complexes to chromatin and thereby influence biological processes. Cancer cells are characterized by prominent epigenetic dysregulation, including histone modifications. However, the functional role...

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Detalles Bibliográficos
Autores principales:	Kondo, Yutaka, Shen, Lanlan, Ahmed, Saira, Boumber, Yanis, Sekido, Yoshitaka, Haddad, Bassem R., Issa, Jean-Pierre J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323574/ https://www.ncbi.nlm.nih.gov/pubmed/18446223 http://dx.doi.org/10.1371/journal.pone.0002037

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