Of Mice, Cattle, and Humans: The Immunology and Treatment of River Blindness

River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite can only develop fully in humans and some pri...

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Autores principales: Allen, Judith E., Adjei, Ohene, Bain, Odile, Hoerauf, Achim, Hoffmann, Wolfgang H., Makepeace, Benjamin L., Schulz-Key, Hartwig, Tanya, Vincent N., Trees, Alexander J., Wanji, Samuel, Taylor, David W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323618/
https://www.ncbi.nlm.nih.gov/pubmed/18446236
http://dx.doi.org/10.1371/journal.pntd.0000217
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author Allen, Judith E.
Adjei, Ohene
Bain, Odile
Hoerauf, Achim
Hoffmann, Wolfgang H.
Makepeace, Benjamin L.
Schulz-Key, Hartwig
Tanya, Vincent N.
Trees, Alexander J.
Wanji, Samuel
Taylor, David W.
author_facet Allen, Judith E.
Adjei, Ohene
Bain, Odile
Hoerauf, Achim
Hoffmann, Wolfgang H.
Makepeace, Benjamin L.
Schulz-Key, Hartwig
Tanya, Vincent N.
Trees, Alexander J.
Wanji, Samuel
Taylor, David W.
author_sort Allen, Judith E.
collection PubMed
description River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite can only develop fully in humans and some primates. This review highlights the development of two animal model systems that have allowed significant advances in recent years and hold promise for the future. Experimental findings with Litomosoides sigmodontis in mice and Onchocerca ochengi in cattle are placed in the context of how these models can advance our ability to control the human disease.
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spelling pubmed-23236182008-04-30 Of Mice, Cattle, and Humans: The Immunology and Treatment of River Blindness Allen, Judith E. Adjei, Ohene Bain, Odile Hoerauf, Achim Hoffmann, Wolfgang H. Makepeace, Benjamin L. Schulz-Key, Hartwig Tanya, Vincent N. Trees, Alexander J. Wanji, Samuel Taylor, David W. PLoS Negl Trop Dis Review River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite can only develop fully in humans and some primates. This review highlights the development of two animal model systems that have allowed significant advances in recent years and hold promise for the future. Experimental findings with Litomosoides sigmodontis in mice and Onchocerca ochengi in cattle are placed in the context of how these models can advance our ability to control the human disease. Public Library of Science 2008-04-30 /pmc/articles/PMC2323618/ /pubmed/18446236 http://dx.doi.org/10.1371/journal.pntd.0000217 Text en Allen et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Review
Allen, Judith E.
Adjei, Ohene
Bain, Odile
Hoerauf, Achim
Hoffmann, Wolfgang H.
Makepeace, Benjamin L.
Schulz-Key, Hartwig
Tanya, Vincent N.
Trees, Alexander J.
Wanji, Samuel
Taylor, David W.
Of Mice, Cattle, and Humans: The Immunology and Treatment of River Blindness
title Of Mice, Cattle, and Humans: The Immunology and Treatment of River Blindness
title_full Of Mice, Cattle, and Humans: The Immunology and Treatment of River Blindness
title_fullStr Of Mice, Cattle, and Humans: The Immunology and Treatment of River Blindness
title_full_unstemmed Of Mice, Cattle, and Humans: The Immunology and Treatment of River Blindness
title_short Of Mice, Cattle, and Humans: The Immunology and Treatment of River Blindness
title_sort of mice, cattle, and humans: the immunology and treatment of river blindness
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323618/
https://www.ncbi.nlm.nih.gov/pubmed/18446236
http://dx.doi.org/10.1371/journal.pntd.0000217
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