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HMG-box domain stimulation of RAG1/2 cleavage activity is metal ion dependent

BACKGROUND: RAG1 and RAG2 initiate V(D)J recombination by assembling a synaptic complex with a pair of antigen receptor gene segments through interactions with their flanking recombination signal sequence (RSS), and then introducing a DNA double-strand break at each RSS, separating it from the adjac...

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Detalles Bibliográficos
Autores principales:	Kriatchko, Aleksei N, Bergeron, Serge, Swanson, Patrick C
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2324110/ https://www.ncbi.nlm.nih.gov/pubmed/18380906 http://dx.doi.org/10.1186/1471-2199-9-32

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