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Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation

BACKGROUND: DNA damage such as double-stranded DNA breaks (DSBs) has been reported to stimulate mitochondrial biogenesis. However, the underlying mechanism is poorly understood. The major player in response to DSBs is ATM (ataxia telangiectasia mutated). Upon sensing DSBs, ATM is activated through a...

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Detalles Bibliográficos
Autores principales:	Fu, Xuan, Wan, Shan, Lyu, Yi Lisa, Liu, Leroy F., Qi, Haiyan
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2329593/ https://www.ncbi.nlm.nih.gov/pubmed/18431490 http://dx.doi.org/10.1371/journal.pone.0002009

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