Differential expression of HOX genes upon activation of leukocyte sub-populations

The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis...

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Detalles Bibliográficos
Autores principales: Morgan, Richard, Whiting, Karen
Formato: Texto
Lenguaje:English
Publicado: Springer Japan 2008
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330060/
https://www.ncbi.nlm.nih.gov/pubmed/18317880
http://dx.doi.org/10.1007/s12185-008-0057-8
Descripción
Sumario:The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis of HOX gene expression in resting and activated lymphocytic and monocytic subpopulations. This has revealed distinct patterns of expression between different cell types and resting and activated states. (Main category A: Erythrocytes, Leukocytes and Hematopoiesis, subcategory: 8: Lymphocytes).

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