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Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form

Crystals of a single-point mutant (T109S) of Escherichia coli dihydroorotase (DHOase) with diminished activity grown in the presence of l-dihydroorotate (l-DHO) are tetragonal, with a monomer in the asymmetric unit. These crystals are extremely unstable and disintegrate shortly after formation, whic...

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Detalles Bibliográficos
Autores principales:	Lee, Mihwa, Maher, Megan J., Guss, J. Mitchell
Formato:	Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2007
Materias:	Protein Structure Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330171/ https://www.ncbi.nlm.nih.gov/pubmed/17329804 http://dx.doi.org/10.1107/S1744309107004009

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