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Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease

BACKGROUND: Huntington's disease (HD) is a neurodegenerative disorder predominantly affecting the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat encoding an expanded polyglutamine tract in the N-terminus of the huntingtin protein, closely model HD. We have pr...

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Detalles Bibliográficos
Autores principales:	van Dellen, Anton, Cordery, Patricia M, Spires, Tara L, Blakemore, Colin, Hannan, Anthony J
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2335112/ https://www.ncbi.nlm.nih.gov/pubmed/18380890 http://dx.doi.org/10.1186/1471-2202-9-34

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