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Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term

OBJECTIVE: To investigate the effect of maternal body mass index (BMI) on postdates pregnancy, length of gestation and likelihood of spontaneous onset of labour at term. DESIGN: Retrospective cohort study. SETTING: Swedish Medical Birth Register. POPULATION: A total of 186 087 primiparous women (of...

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Autores principales: Denison, FC, Price, J, Graham, C, Wild, S, Liston, WA
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2344995/
https://www.ncbi.nlm.nih.gov/pubmed/18410655
http://dx.doi.org/10.1111/j.1471-0528.2008.01694.x
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author Denison, FC
Price, J
Graham, C
Wild, S
Liston, WA
author_facet Denison, FC
Price, J
Graham, C
Wild, S
Liston, WA
author_sort Denison, FC
collection PubMed
description OBJECTIVE: To investigate the effect of maternal body mass index (BMI) on postdates pregnancy, length of gestation and likelihood of spontaneous onset of labour at term. DESIGN: Retrospective cohort study. SETTING: Swedish Medical Birth Register. POPULATION: A total of 186 087 primiparous women (of whom 143 519 had spontaneous onset of labour at term) who gave birth between 1998 and 2002. METHODS: Mann–Whitney test, one-way analysis of variance, linear regression and single variable logistic regression. MAIN OUTCOME MEASURES: Postdates pregnancy (≥294 days or 42(+0) weeks), length of gestation and likelihood of spontaneous onset of labour at term. RESULTS: About 6.8% of pregnancies delivered postdates. Higher maternal BMI (kg/m(2)) during the first trimester was associated with longer gestation (P < 0.001) as was a greater change in BMI between the first and third trimesters (BMI measured on admission prior to delivery) with mean (SD) gestation at delivery of 280.7 (8.6) and 283.2 (8.6) days for increases in BMI of <2 and ≥10 kg/m(2), respectively. Higher BMI during the first trimester was associated with a lower chance of spontaneous onset of labour at term. Compared with BMI 20 to <25 kg/m(2), the odds ratios (95% CI) for spontaneous onset of labour at term were 1.21 (1.15–1.27) for BMI of <20 kg/m(2), 0.71 (0.69–0.74) for BMI of 25 to <30 kg/m(2), 0.57 (0.54–0.60) for BMI of 30 to <35 kg/m(2) and 0.43 (0.40–0.47) for BMI of ≥35 kg/m(2). Higher BMI during the first trimester (BMI of ≥35 kg/m(2) compared with BMI of 20 to <25 kg/m(2)) was also associated with an increased risk of complications including stillbirth (OR 3.90, 95% CI 2.44–6.22), gestational diabetes (OR 5.61, 95% CI 4.61–6.83) and caesarean section (OR 2.39; 95% CI 2.20–2.59). CONCLUSIONS: Higher maternal BMI in the first trimester and a greater change in BMI during pregnancy were associated with longer gestation and an increased risk of postdates pregnancy. Higher maternal BMI during the first trimester was also associated with decreased likelihood of spontaneous onset of labour at term and increased likelihood of complications. Please cite this paper as: Denison F, Price J, Graham C, Wild S, Liston W. Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term. BJOG 2008;115:720–725.
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spelling pubmed-23449952008-04-28 Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term Denison, FC Price, J Graham, C Wild, S Liston, WA BJOG General Obstetrics OBJECTIVE: To investigate the effect of maternal body mass index (BMI) on postdates pregnancy, length of gestation and likelihood of spontaneous onset of labour at term. DESIGN: Retrospective cohort study. SETTING: Swedish Medical Birth Register. POPULATION: A total of 186 087 primiparous women (of whom 143 519 had spontaneous onset of labour at term) who gave birth between 1998 and 2002. METHODS: Mann–Whitney test, one-way analysis of variance, linear regression and single variable logistic regression. MAIN OUTCOME MEASURES: Postdates pregnancy (≥294 days or 42(+0) weeks), length of gestation and likelihood of spontaneous onset of labour at term. RESULTS: About 6.8% of pregnancies delivered postdates. Higher maternal BMI (kg/m(2)) during the first trimester was associated with longer gestation (P < 0.001) as was a greater change in BMI between the first and third trimesters (BMI measured on admission prior to delivery) with mean (SD) gestation at delivery of 280.7 (8.6) and 283.2 (8.6) days for increases in BMI of <2 and ≥10 kg/m(2), respectively. Higher BMI during the first trimester was associated with a lower chance of spontaneous onset of labour at term. Compared with BMI 20 to <25 kg/m(2), the odds ratios (95% CI) for spontaneous onset of labour at term were 1.21 (1.15–1.27) for BMI of <20 kg/m(2), 0.71 (0.69–0.74) for BMI of 25 to <30 kg/m(2), 0.57 (0.54–0.60) for BMI of 30 to <35 kg/m(2) and 0.43 (0.40–0.47) for BMI of ≥35 kg/m(2). Higher BMI during the first trimester (BMI of ≥35 kg/m(2) compared with BMI of 20 to <25 kg/m(2)) was also associated with an increased risk of complications including stillbirth (OR 3.90, 95% CI 2.44–6.22), gestational diabetes (OR 5.61, 95% CI 4.61–6.83) and caesarean section (OR 2.39; 95% CI 2.20–2.59). CONCLUSIONS: Higher maternal BMI in the first trimester and a greater change in BMI during pregnancy were associated with longer gestation and an increased risk of postdates pregnancy. Higher maternal BMI during the first trimester was also associated with decreased likelihood of spontaneous onset of labour at term and increased likelihood of complications. Please cite this paper as: Denison F, Price J, Graham C, Wild S, Liston W. Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term. BJOG 2008;115:720–725. Blackwell Publishing Ltd 2008-05-01 /pmc/articles/PMC2344995/ /pubmed/18410655 http://dx.doi.org/10.1111/j.1471-0528.2008.01694.x Text en © 2008 The Authors Journal compilation © RCOG 2008 BJOG An International Journal of Obstetrics and Gynaecology https://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle General Obstetrics
Denison, FC
Price, J
Graham, C
Wild, S
Liston, WA
Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term
title Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term
title_full Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term
title_fullStr Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term
title_full_unstemmed Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term
title_short Maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term
title_sort maternal obesity, length of gestation, risk of postdates pregnancy and spontaneous onset of labour at term
topic General Obstetrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2344995/
https://www.ncbi.nlm.nih.gov/pubmed/18410655
http://dx.doi.org/10.1111/j.1471-0528.2008.01694.x
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