Cargando…

Adult nontwin sib concordance rates for type 2 diabetes, hypertension and metabolic syndrome among Asian Indians: The Indian Atherosclerosis Research Study

Diabetes (DM), hypertension (HTN), and metabolic syndrome (MS) are established cardiovascular risk factors with a complex etiology. The aim of the present study was to estimate the rates of concordance for the above coronary risk factors between siblings in Asian Indian families with premature coron...

Descripción completa

Detalles Bibliográficos
Autores principales: Shanker, Jayashree, Kanjilal, Saikat, Rao, Veena S, Perumal, Ganapathy, Khadrinarasimhiah, Natesha B, Mukherjee, Manjari, Iyengar, Shamanna S, Kakkar, Vijay V
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2350127/
https://www.ncbi.nlm.nih.gov/pubmed/18200825
_version_ 1782152852618084352
author Shanker, Jayashree
Kanjilal, Saikat
Rao, Veena S
Perumal, Ganapathy
Khadrinarasimhiah, Natesha B
Mukherjee, Manjari
Iyengar, Shamanna S
Kakkar, Vijay V
author_facet Shanker, Jayashree
Kanjilal, Saikat
Rao, Veena S
Perumal, Ganapathy
Khadrinarasimhiah, Natesha B
Mukherjee, Manjari
Iyengar, Shamanna S
Kakkar, Vijay V
author_sort Shanker, Jayashree
collection PubMed
description Diabetes (DM), hypertension (HTN), and metabolic syndrome (MS) are established cardiovascular risk factors with a complex etiology. The aim of the present study was to estimate the rates of concordance for the above coronary risk factors between siblings in Asian Indian families with premature coronary artery disease (CAD). Spouse concordance rates were used to evaluate the relative contribution of shared genes and lifestyle towards these traits. A total of 508 families comprising of 1250 sib-pairs and 463 corresponding spouse-pairs were analyzed. Concordance rates were manually determined. Plasma lipids were estimated by standard enzymatic assay. The concordance rates among sib-pairs for DM, HTN, and MS was 11% (N = 136), 14% (N = 174), and 23% (N = 287), while the corresponding concordance for spouse-pairs was 2.8% (N = 13), 6.3% (N = 29), and 28.1% (N = 130), respectively. Employing Chi-square test, sib-pairs showed significantly higher concordance for diabetes (p ≤ 0.0001) and hypertension (p < 0.0001) while spouse-pairs had higher concordance for metabolic syndrome (p = 0.033) in our study. These findings suggest a probable dominant genetic component in the causation of DM and HTN and a predominantly nongenetic component for metabolic syndrome among Asian Indians.
format Text
id pubmed-2350127
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-23501272008-05-08 Adult nontwin sib concordance rates for type 2 diabetes, hypertension and metabolic syndrome among Asian Indians: The Indian Atherosclerosis Research Study Shanker, Jayashree Kanjilal, Saikat Rao, Veena S Perumal, Ganapathy Khadrinarasimhiah, Natesha B Mukherjee, Manjari Iyengar, Shamanna S Kakkar, Vijay V Vasc Health Risk Manag Original Research Diabetes (DM), hypertension (HTN), and metabolic syndrome (MS) are established cardiovascular risk factors with a complex etiology. The aim of the present study was to estimate the rates of concordance for the above coronary risk factors between siblings in Asian Indian families with premature coronary artery disease (CAD). Spouse concordance rates were used to evaluate the relative contribution of shared genes and lifestyle towards these traits. A total of 508 families comprising of 1250 sib-pairs and 463 corresponding spouse-pairs were analyzed. Concordance rates were manually determined. Plasma lipids were estimated by standard enzymatic assay. The concordance rates among sib-pairs for DM, HTN, and MS was 11% (N = 136), 14% (N = 174), and 23% (N = 287), while the corresponding concordance for spouse-pairs was 2.8% (N = 13), 6.3% (N = 29), and 28.1% (N = 130), respectively. Employing Chi-square test, sib-pairs showed significantly higher concordance for diabetes (p ≤ 0.0001) and hypertension (p < 0.0001) while spouse-pairs had higher concordance for metabolic syndrome (p = 0.033) in our study. These findings suggest a probable dominant genetic component in the causation of DM and HTN and a predominantly nongenetic component for metabolic syndrome among Asian Indians. Dove Medical Press 2007-12 /pmc/articles/PMC2350127/ /pubmed/18200825 Text en © 2007 Shanker et al, publisher and licensee Dove Medical Press Ltd.
spellingShingle Original Research
Shanker, Jayashree
Kanjilal, Saikat
Rao, Veena S
Perumal, Ganapathy
Khadrinarasimhiah, Natesha B
Mukherjee, Manjari
Iyengar, Shamanna S
Kakkar, Vijay V
Adult nontwin sib concordance rates for type 2 diabetes, hypertension and metabolic syndrome among Asian Indians: The Indian Atherosclerosis Research Study
title Adult nontwin sib concordance rates for type 2 diabetes, hypertension and metabolic syndrome among Asian Indians: The Indian Atherosclerosis Research Study
title_full Adult nontwin sib concordance rates for type 2 diabetes, hypertension and metabolic syndrome among Asian Indians: The Indian Atherosclerosis Research Study
title_fullStr Adult nontwin sib concordance rates for type 2 diabetes, hypertension and metabolic syndrome among Asian Indians: The Indian Atherosclerosis Research Study
title_full_unstemmed Adult nontwin sib concordance rates for type 2 diabetes, hypertension and metabolic syndrome among Asian Indians: The Indian Atherosclerosis Research Study
title_short Adult nontwin sib concordance rates for type 2 diabetes, hypertension and metabolic syndrome among Asian Indians: The Indian Atherosclerosis Research Study
title_sort adult nontwin sib concordance rates for type 2 diabetes, hypertension and metabolic syndrome among asian indians: the indian atherosclerosis research study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2350127/
https://www.ncbi.nlm.nih.gov/pubmed/18200825
work_keys_str_mv AT shankerjayashree adultnontwinsibconcordanceratesfortype2diabeteshypertensionandmetabolicsyndromeamongasianindianstheindianatherosclerosisresearchstudy
AT kanjilalsaikat adultnontwinsibconcordanceratesfortype2diabeteshypertensionandmetabolicsyndromeamongasianindianstheindianatherosclerosisresearchstudy
AT raoveenas adultnontwinsibconcordanceratesfortype2diabeteshypertensionandmetabolicsyndromeamongasianindianstheindianatherosclerosisresearchstudy
AT perumalganapathy adultnontwinsibconcordanceratesfortype2diabeteshypertensionandmetabolicsyndromeamongasianindianstheindianatherosclerosisresearchstudy
AT khadrinarasimhiahnateshab adultnontwinsibconcordanceratesfortype2diabeteshypertensionandmetabolicsyndromeamongasianindianstheindianatherosclerosisresearchstudy
AT mukherjeemanjari adultnontwinsibconcordanceratesfortype2diabeteshypertensionandmetabolicsyndromeamongasianindianstheindianatherosclerosisresearchstudy
AT iyengarshamannas adultnontwinsibconcordanceratesfortype2diabeteshypertensionandmetabolicsyndromeamongasianindianstheindianatherosclerosisresearchstudy
AT kakkarvijayv adultnontwinsibconcordanceratesfortype2diabeteshypertensionandmetabolicsyndromeamongasianindianstheindianatherosclerosisresearchstudy