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A prospective evaluation of persistence on antihypertensive treatment with different antihypertensive drugs in clinical practice

Persistence on treatment affects the efficacy of antihypertensive treatment. We prospectively investigated the persistence on therapy and the extent of blood pressure (BP) control in 347 hypertensive patients (age 59.4 ± 6 years) randomly allocated to a first-line treatment with: angiotensin-convert...

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Autores principales: Veronesi, Maddalena, Cicero, Arrigo FG, Prandin, Maria Grazia, Dormi, Ada, Cosentino, Eugenio, Strocchi, Enrico, Borghi, Claudio
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2350135/
https://www.ncbi.nlm.nih.gov/pubmed/18200818
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author Veronesi, Maddalena
Cicero, Arrigo FG
Prandin, Maria Grazia
Dormi, Ada
Cosentino, Eugenio
Strocchi, Enrico
Borghi, Claudio
author_facet Veronesi, Maddalena
Cicero, Arrigo FG
Prandin, Maria Grazia
Dormi, Ada
Cosentino, Eugenio
Strocchi, Enrico
Borghi, Claudio
author_sort Veronesi, Maddalena
collection PubMed
description Persistence on treatment affects the efficacy of antihypertensive treatment. We prospectively investigated the persistence on therapy and the extent of blood pressure (BP) control in 347 hypertensive patients (age 59.4 ± 6 years) randomly allocated to a first-line treatment with: angiotensin-converting enzyme (ACE) inhibitors, calcium-channel blockers (CCBs), ß-blockers, angiotensin-II receptor blockers (ARBs), or diuretics and followed-up for 24-months. Persistence on treatment was higher in patients treated with ARBs (68.5%) and ACE inhibitors (64.5%) vs CCBs (51.6%; p < 0.05), β-blockers (44.8%, p < 0.05), and diuretics (34.4%, p < 0.01). No ARB, ACE inhibitor, β-blocker, or diuretic was associated with a higher persistence in therapy compared with the other molecules used in each therapeutic class. The rate of persistence was significantly higher in patients treated with lercanidipine vs others CCBs (59.3% vs 46.6%, p < 0.05). Systolic and diastolic BP was decreased more successfully in patients treated with ARBs (−11.2/−5.8 mmHg), ACE inhibitors (−10.5/−5.1 mmHg), and CCBs (−8.5/−4.6 mmHg) compared with ß-blockers (−4.0/−2.3 mmHg p < 0.05) and diuretics (−2.3/−2.1 mmHg, p < 0.05). No ARB, ACE inhibitor, β-blocker, or diuretic was associated with a higher BP control compared with the other molecules used in each therapeutic class. A trend toward a better BP control was observed in response to lercanidipine vs other CCBs (p = 0.059). The present results confirm the importance of persistence on treatment for the management of hypertension in clinical practice.
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spelling pubmed-23501352008-05-08 A prospective evaluation of persistence on antihypertensive treatment with different antihypertensive drugs in clinical practice Veronesi, Maddalena Cicero, Arrigo FG Prandin, Maria Grazia Dormi, Ada Cosentino, Eugenio Strocchi, Enrico Borghi, Claudio Vasc Health Risk Manag Original Research Persistence on treatment affects the efficacy of antihypertensive treatment. We prospectively investigated the persistence on therapy and the extent of blood pressure (BP) control in 347 hypertensive patients (age 59.4 ± 6 years) randomly allocated to a first-line treatment with: angiotensin-converting enzyme (ACE) inhibitors, calcium-channel blockers (CCBs), ß-blockers, angiotensin-II receptor blockers (ARBs), or diuretics and followed-up for 24-months. Persistence on treatment was higher in patients treated with ARBs (68.5%) and ACE inhibitors (64.5%) vs CCBs (51.6%; p < 0.05), β-blockers (44.8%, p < 0.05), and diuretics (34.4%, p < 0.01). No ARB, ACE inhibitor, β-blocker, or diuretic was associated with a higher persistence in therapy compared with the other molecules used in each therapeutic class. The rate of persistence was significantly higher in patients treated with lercanidipine vs others CCBs (59.3% vs 46.6%, p < 0.05). Systolic and diastolic BP was decreased more successfully in patients treated with ARBs (−11.2/−5.8 mmHg), ACE inhibitors (−10.5/−5.1 mmHg), and CCBs (−8.5/−4.6 mmHg) compared with ß-blockers (−4.0/−2.3 mmHg p < 0.05) and diuretics (−2.3/−2.1 mmHg, p < 0.05). No ARB, ACE inhibitor, β-blocker, or diuretic was associated with a higher BP control compared with the other molecules used in each therapeutic class. A trend toward a better BP control was observed in response to lercanidipine vs other CCBs (p = 0.059). The present results confirm the importance of persistence on treatment for the management of hypertension in clinical practice. Dove Medical Press 2007-12 /pmc/articles/PMC2350135/ /pubmed/18200818 Text en © 2007 Dove Medical Press Limited. All rights reserved
spellingShingle Original Research
Veronesi, Maddalena
Cicero, Arrigo FG
Prandin, Maria Grazia
Dormi, Ada
Cosentino, Eugenio
Strocchi, Enrico
Borghi, Claudio
A prospective evaluation of persistence on antihypertensive treatment with different antihypertensive drugs in clinical practice
title A prospective evaluation of persistence on antihypertensive treatment with different antihypertensive drugs in clinical practice
title_full A prospective evaluation of persistence on antihypertensive treatment with different antihypertensive drugs in clinical practice
title_fullStr A prospective evaluation of persistence on antihypertensive treatment with different antihypertensive drugs in clinical practice
title_full_unstemmed A prospective evaluation of persistence on antihypertensive treatment with different antihypertensive drugs in clinical practice
title_short A prospective evaluation of persistence on antihypertensive treatment with different antihypertensive drugs in clinical practice
title_sort prospective evaluation of persistence on antihypertensive treatment with different antihypertensive drugs in clinical practice
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2350135/
https://www.ncbi.nlm.nih.gov/pubmed/18200818
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