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Evolution of pharmacologic specificity in the pregnane X receptor

BACKGROUND: The pregnane X receptor (PXR) shows the highest degree of cross-species sequence diversity of any of the vertebrate nuclear hormone receptors. In this study, we determined the pharmacophores for activation of human, mouse, rat, rabbit, chicken, and zebrafish PXRs, using a common set of s...

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Detalles Bibliográficos
Autores principales:	Ekins, Sean, Reschly, Erica J, Hagey, Lee R, Krasowski, Matthew D
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2358886/ https://www.ncbi.nlm.nih.gov/pubmed/18384689 http://dx.doi.org/10.1186/1471-2148-8-103

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