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Cyclopentenyl cytosine increases gemcitabine radiosensitisation in human pancreatic cancer cells

The deoxycytidine analogue 2′,2′-difluoro-2′-deoxycytidine (dFdC, gemcitabine) is a potent radiosensitiser, but has limited efficacy in combination with radiotherapy in patients with pancreatic cancer due to acute toxicity. We investigated whether cyclopentenyl cytosine (CPEC), targetting the ‘de no...

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Detalles Bibliográficos
Autores principales:	van Bree, C, Rodermond, H M, Leen, R, Medema, J P, van Kuilenburg, A B P
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2008
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359636/ https://www.ncbi.nlm.nih.gov/pubmed/18349845 http://dx.doi.org/10.1038/sj.bjc.6604287

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