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Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts

Insulin-like growth factor (IGF)-I induces growth in pancreatic cancer cells and blockade of the IGF-I receptor has antitumour activity. The association of plasma IGF-I and IGF binding protein-3 (IGFBP-3) with pancreatic cancer risk has been investigated in two small studies, with conflicting result...

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Autores principales: Wolpin, B M, Michaud, D S, Giovannucci, E L, Schernhammer, E S, Stampfer, M J, Manson, J E, Cochrane, B B, Rohan, T E, Ma, J, Pollak, M N, Fuchs, C S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359655/
https://www.ncbi.nlm.nih.gov/pubmed/17533398
http://dx.doi.org/10.1038/sj.bjc.6603826
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author Wolpin, B M
Michaud, D S
Giovannucci, E L
Schernhammer, E S
Stampfer, M J
Manson, J E
Cochrane, B B
Rohan, T E
Ma, J
Pollak, M N
Fuchs, C S
author_facet Wolpin, B M
Michaud, D S
Giovannucci, E L
Schernhammer, E S
Stampfer, M J
Manson, J E
Cochrane, B B
Rohan, T E
Ma, J
Pollak, M N
Fuchs, C S
author_sort Wolpin, B M
collection PubMed
description Insulin-like growth factor (IGF)-I induces growth in pancreatic cancer cells and blockade of the IGF-I receptor has antitumour activity. The association of plasma IGF-I and IGF binding protein-3 (IGFBP-3) with pancreatic cancer risk has been investigated in two small studies, with conflicting results. We conducted a nested case–control study within four large, prospective cohorts to investigate whether prediagnostic plasma levels of IGF-I, IGF-II, and IGFBP-3 were associated with pancreatic cancer risk. Plasma levels in 212 cases and 635 matched controls were compared by conditional logistic regression, with adjustment for other known pancreatic cancer risk factors. No association was observed between plasma levels of IGF-I, IGF-II, or IGFBP-3 and incident diagnosis of pancreatic cancer. Relative risks for the highest vs the lowest quartile of IGF-I, IGF-II, and IGFBP-3 were 0.94 (95% confidence interval (CI), 0.60–1.48), 0.96 (95% CI, 0.61–1.52), and 1.21 (95% CI, 0.75–1.92), respectively. The relative risk for the molar ratio of IGF-I and IGFBP-3, a surrogate measure for free IGF-I, was 0.84 (95% CI, 0.54–1.31). Additionally, no association was noted in stratified analyses or when requiring longer follow-up. In four prospective cohorts, we found no association between the risk of pancreatic cancer and prediagnostic plasma levels of IGF-I, IGF-II, or IGFBP-3.
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spelling pubmed-23596552009-09-10 Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts Wolpin, B M Michaud, D S Giovannucci, E L Schernhammer, E S Stampfer, M J Manson, J E Cochrane, B B Rohan, T E Ma, J Pollak, M N Fuchs, C S Br J Cancer Molecular Diagnostics Insulin-like growth factor (IGF)-I induces growth in pancreatic cancer cells and blockade of the IGF-I receptor has antitumour activity. The association of plasma IGF-I and IGF binding protein-3 (IGFBP-3) with pancreatic cancer risk has been investigated in two small studies, with conflicting results. We conducted a nested case–control study within four large, prospective cohorts to investigate whether prediagnostic plasma levels of IGF-I, IGF-II, and IGFBP-3 were associated with pancreatic cancer risk. Plasma levels in 212 cases and 635 matched controls were compared by conditional logistic regression, with adjustment for other known pancreatic cancer risk factors. No association was observed between plasma levels of IGF-I, IGF-II, or IGFBP-3 and incident diagnosis of pancreatic cancer. Relative risks for the highest vs the lowest quartile of IGF-I, IGF-II, and IGFBP-3 were 0.94 (95% confidence interval (CI), 0.60–1.48), 0.96 (95% CI, 0.61–1.52), and 1.21 (95% CI, 0.75–1.92), respectively. The relative risk for the molar ratio of IGF-I and IGFBP-3, a surrogate measure for free IGF-I, was 0.84 (95% CI, 0.54–1.31). Additionally, no association was noted in stratified analyses or when requiring longer follow-up. In four prospective cohorts, we found no association between the risk of pancreatic cancer and prediagnostic plasma levels of IGF-I, IGF-II, or IGFBP-3. Nature Publishing Group 2007-07-02 2007-05-29 /pmc/articles/PMC2359655/ /pubmed/17533398 http://dx.doi.org/10.1038/sj.bjc.6603826 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular Diagnostics
Wolpin, B M
Michaud, D S
Giovannucci, E L
Schernhammer, E S
Stampfer, M J
Manson, J E
Cochrane, B B
Rohan, T E
Ma, J
Pollak, M N
Fuchs, C S
Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts
title Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts
title_full Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts
title_fullStr Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts
title_full_unstemmed Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts
title_short Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts
title_sort circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359655/
https://www.ncbi.nlm.nih.gov/pubmed/17533398
http://dx.doi.org/10.1038/sj.bjc.6603826
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