Updates on p53: modulation of p53 degradation as a therapeutic approach

The p53 pathway is aberrant in most human tumours with over 50% expressing mutant p53 proteins. The pathway is critically controlled by protein degradation. Here, we discuss the latest developments in the search for small molecules that can modulate p53 pathway protein stability and restore p53 acti...

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Detalles Bibliográficos
Autores principales: Dey, A, Verma, C S, Lane, D P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359710/
https://www.ncbi.nlm.nih.gov/pubmed/18182973
http://dx.doi.org/10.1038/sj.bjc.6604098
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author Dey, A
Verma, C S
Lane, D P
author_facet Dey, A
Verma, C S
Lane, D P
author_sort Dey, A
collection PubMed
description The p53 pathway is aberrant in most human tumours with over 50% expressing mutant p53 proteins. The pathway is critically controlled by protein degradation. Here, we discuss the latest developments in the search for small molecules that can modulate p53 pathway protein stability and restore p53 activity for cancer therapy.
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spelling pubmed-23597102009-09-10 Updates on p53: modulation of p53 degradation as a therapeutic approach Dey, A Verma, C S Lane, D P Br J Cancer Review The p53 pathway is aberrant in most human tumours with over 50% expressing mutant p53 proteins. The pathway is critically controlled by protein degradation. Here, we discuss the latest developments in the search for small molecules that can modulate p53 pathway protein stability and restore p53 activity for cancer therapy. Nature Publishing Group 2008-01-15 2008-01-08 /pmc/articles/PMC2359710/ /pubmed/18182973 http://dx.doi.org/10.1038/sj.bjc.6604098 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Dey, A
Verma, C S
Lane, D P
Updates on p53: modulation of p53 degradation as a therapeutic approach
title Updates on p53: modulation of p53 degradation as a therapeutic approach
title_full Updates on p53: modulation of p53 degradation as a therapeutic approach
title_fullStr Updates on p53: modulation of p53 degradation as a therapeutic approach
title_full_unstemmed Updates on p53: modulation of p53 degradation as a therapeutic approach
title_short Updates on p53: modulation of p53 degradation as a therapeutic approach
title_sort updates on p53: modulation of p53 degradation as a therapeutic approach
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359710/
https://www.ncbi.nlm.nih.gov/pubmed/18182973
http://dx.doi.org/10.1038/sj.bjc.6604098
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