Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations

Patients with multiple (5–100) colorectal adenomas (MCRAs) often have no germline mutation in known predisposition genes, but probably have a genetic origin. We collected a set of 25 MCRA patients with no detectable germline mutation in APC, MYH/MUTYH or the mismatch repair genes. Extracolonic tumou...

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Detalles Bibliográficos
Autores principales: Thirlwell, C, Howarth, K M, Segditsas, S, Guerra, G, Thomas, H J W, Phillips, R K S, Talbot, I C, Gorman, M, Novelli, M R, Sieber, O M, Tomlinson, I P M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359923/
https://www.ncbi.nlm.nih.gov/pubmed/17505512
http://dx.doi.org/10.1038/sj.bjc.6603789

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