Expression of IP-10 related to angiogenesis in uterine cervical cancers

Angiogenesis is essential for development, growth and advancement of solid tumours. Interferon-γ-inducible protein 10 (IP-10) regulates lymphocyte chemotaxis, mediates vascular pericyte proliferation and acts as an angiostatic agent, thus inhibiting tumour growth. This prompted us to study the clini...

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Autores principales: Sato, E, Fujimoto, J, Toyoki, H, Sakaguchi, H, Alam, S M, Jahan, I, Tamaya, T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359925/
https://www.ncbi.nlm.nih.gov/pubmed/17505511
http://dx.doi.org/10.1038/sj.bjc.6603790
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author Sato, E
Fujimoto, J
Toyoki, H
Sakaguchi, H
Alam, S M
Jahan, I
Tamaya, T
author_facet Sato, E
Fujimoto, J
Toyoki, H
Sakaguchi, H
Alam, S M
Jahan, I
Tamaya, T
author_sort Sato, E
collection PubMed
description Angiogenesis is essential for development, growth and advancement of solid tumours. Interferon-γ-inducible protein 10 (IP-10) regulates lymphocyte chemotaxis, mediates vascular pericyte proliferation and acts as an angiostatic agent, thus inhibiting tumour growth. This prompted us to study the clinical implications of IP-10 expression related to angiogenesis in uterine cervical cancers. The levels of IP-10 decreased with advancement, and the prognosis of the 30 patients with low IP-10 expression in uterine cervical cancers was poor (66%), whereas the 24-month survival rate of the other patients with high IP-10 expression was 90%. Furthermore, IP-10 levels significantly reverse-correlated with vascular endothelial growth factor (VEGF) levels in uterine cervical cancers. Interferon-γ-inducible protein 10 might work on suppression of angiogenesis associated with VEGF in advancement, and can be recognised as a prognostic indicator. Furthermore, IP-10 activation might be effective on the suppression of regrowth or recurrence after intensive treatment for advanced cervical cancers.
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spelling pubmed-23599252009-09-10 Expression of IP-10 related to angiogenesis in uterine cervical cancers Sato, E Fujimoto, J Toyoki, H Sakaguchi, H Alam, S M Jahan, I Tamaya, T Br J Cancer Molecular Diagnostics Angiogenesis is essential for development, growth and advancement of solid tumours. Interferon-γ-inducible protein 10 (IP-10) regulates lymphocyte chemotaxis, mediates vascular pericyte proliferation and acts as an angiostatic agent, thus inhibiting tumour growth. This prompted us to study the clinical implications of IP-10 expression related to angiogenesis in uterine cervical cancers. The levels of IP-10 decreased with advancement, and the prognosis of the 30 patients with low IP-10 expression in uterine cervical cancers was poor (66%), whereas the 24-month survival rate of the other patients with high IP-10 expression was 90%. Furthermore, IP-10 levels significantly reverse-correlated with vascular endothelial growth factor (VEGF) levels in uterine cervical cancers. Interferon-γ-inducible protein 10 might work on suppression of angiogenesis associated with VEGF in advancement, and can be recognised as a prognostic indicator. Furthermore, IP-10 activation might be effective on the suppression of regrowth or recurrence after intensive treatment for advanced cervical cancers. Nature Publishing Group 2007-06-04 2007-05-15 /pmc/articles/PMC2359925/ /pubmed/17505511 http://dx.doi.org/10.1038/sj.bjc.6603790 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular Diagnostics
Sato, E
Fujimoto, J
Toyoki, H
Sakaguchi, H
Alam, S M
Jahan, I
Tamaya, T
Expression of IP-10 related to angiogenesis in uterine cervical cancers
title Expression of IP-10 related to angiogenesis in uterine cervical cancers
title_full Expression of IP-10 related to angiogenesis in uterine cervical cancers
title_fullStr Expression of IP-10 related to angiogenesis in uterine cervical cancers
title_full_unstemmed Expression of IP-10 related to angiogenesis in uterine cervical cancers
title_short Expression of IP-10 related to angiogenesis in uterine cervical cancers
title_sort expression of ip-10 related to angiogenesis in uterine cervical cancers
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359925/
https://www.ncbi.nlm.nih.gov/pubmed/17505511
http://dx.doi.org/10.1038/sj.bjc.6603790
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