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The impact of regulatory T cells on carcinogen-induced sarcogenesis
Burnet proposed in the 1950's that the immune system is engaged in identifying and destroying abnormal cancerous cells. This process, termed immune surveillance, has been at the centre of intense debate for decades. Results using immunodeficient mice lend support to the immune surveillance hypo...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359957/ https://www.ncbi.nlm.nih.gov/pubmed/17565340 http://dx.doi.org/10.1038/sj.bjc.6603824 |
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author | Betts, G Twohig, J Van den Broek, M Sierro, S Godkin, A Gallimore, A |
author_facet | Betts, G Twohig, J Van den Broek, M Sierro, S Godkin, A Gallimore, A |
author_sort | Betts, G |
collection | PubMed |
description | Burnet proposed in the 1950's that the immune system is engaged in identifying and destroying abnormal cancerous cells. This process, termed immune surveillance, has been at the centre of intense debate for decades. Results using immunodeficient mice lend support to the immune surveillance hypothesis. We surmised that immune surveillance would be hampered by the inhibitory effect of naturally occurring FoxP3(+) regulatory T cells, a population of T cells shown to be present at an increased frequency in a variety of human tumours. The carcinogen, methylcholanthrene was injected subcutaneously into mice and the steady development of fibrosarcomas was observed over approximately 200 days. These fibrosarcomas were strikingly infiltrated with FoxP3(+) regulatory T cells implying that these cells impinge upon immune-mediated rejection of the tumour. This was confirmed by partial ablation of FoxP3(+) regulatory T-cell activity, which resulted in a marked reduction in tumour incidence. The reduction of tumour incidence was ablated in mice that lacked interferon gamma. These data offer strong support for the concept of immune surveillance and indicate that this process is limited by the inhibitory effect of FoxP3(+) regulatory T cells. |
format | Text |
id | pubmed-2359957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23599572009-09-10 The impact of regulatory T cells on carcinogen-induced sarcogenesis Betts, G Twohig, J Van den Broek, M Sierro, S Godkin, A Gallimore, A Br J Cancer Translational Therapeutics Burnet proposed in the 1950's that the immune system is engaged in identifying and destroying abnormal cancerous cells. This process, termed immune surveillance, has been at the centre of intense debate for decades. Results using immunodeficient mice lend support to the immune surveillance hypothesis. We surmised that immune surveillance would be hampered by the inhibitory effect of naturally occurring FoxP3(+) regulatory T cells, a population of T cells shown to be present at an increased frequency in a variety of human tumours. The carcinogen, methylcholanthrene was injected subcutaneously into mice and the steady development of fibrosarcomas was observed over approximately 200 days. These fibrosarcomas were strikingly infiltrated with FoxP3(+) regulatory T cells implying that these cells impinge upon immune-mediated rejection of the tumour. This was confirmed by partial ablation of FoxP3(+) regulatory T-cell activity, which resulted in a marked reduction in tumour incidence. The reduction of tumour incidence was ablated in mice that lacked interferon gamma. These data offer strong support for the concept of immune surveillance and indicate that this process is limited by the inhibitory effect of FoxP3(+) regulatory T cells. Nature Publishing Group 2007-06-18 2007-06-12 /pmc/articles/PMC2359957/ /pubmed/17565340 http://dx.doi.org/10.1038/sj.bjc.6603824 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Translational Therapeutics Betts, G Twohig, J Van den Broek, M Sierro, S Godkin, A Gallimore, A The impact of regulatory T cells on carcinogen-induced sarcogenesis |
title | The impact of regulatory T cells on carcinogen-induced sarcogenesis |
title_full | The impact of regulatory T cells on carcinogen-induced sarcogenesis |
title_fullStr | The impact of regulatory T cells on carcinogen-induced sarcogenesis |
title_full_unstemmed | The impact of regulatory T cells on carcinogen-induced sarcogenesis |
title_short | The impact of regulatory T cells on carcinogen-induced sarcogenesis |
title_sort | impact of regulatory t cells on carcinogen-induced sarcogenesis |
topic | Translational Therapeutics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359957/ https://www.ncbi.nlm.nih.gov/pubmed/17565340 http://dx.doi.org/10.1038/sj.bjc.6603824 |
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