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Desmosomes: a role in cancer?
Much evidence now attests to the importance of desmosomes and their constituents in cancer. Alterations in the expression of desmosomal components could contribute to the progression of the disease by modifying intracellular signal transduction pathways and/or by causing reduced cell adhesion. The W...
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| Formato: | Texto |
| Lenguaje: | English |
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Nature Publishing Group
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359958/ https://www.ncbi.nlm.nih.gov/pubmed/17519903 http://dx.doi.org/10.1038/sj.bjc.6603808 |
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| author | Chidgey, M Dawson, C |
| author_facet | Chidgey, M Dawson, C |
| author_sort | Chidgey, M |
| collection | PubMed |
| description | Much evidence now attests to the importance of desmosomes and their constituents in cancer. Alterations in the expression of desmosomal components could contribute to the progression of the disease by modifying intracellular signal transduction pathways and/or by causing reduced cell adhesion. The Wnt/β-catenin pathway is a potential target because of the involvement of the cytoplasmic desmosomal protein plakoglobin. Loss of desmosomal adhesion is a prerequisite for the epithelial–mesenchymal transition, implicated in the conversion of early stage tumours to invasive cancers. |
| format | Text |
| id | pubmed-2359958 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2007 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-23599582009-09-10 Desmosomes: a role in cancer? Chidgey, M Dawson, C Br J Cancer Minireview Much evidence now attests to the importance of desmosomes and their constituents in cancer. Alterations in the expression of desmosomal components could contribute to the progression of the disease by modifying intracellular signal transduction pathways and/or by causing reduced cell adhesion. The Wnt/β-catenin pathway is a potential target because of the involvement of the cytoplasmic desmosomal protein plakoglobin. Loss of desmosomal adhesion is a prerequisite for the epithelial–mesenchymal transition, implicated in the conversion of early stage tumours to invasive cancers. Nature Publishing Group 2007-06-18 2007-05-22 /pmc/articles/PMC2359958/ /pubmed/17519903 http://dx.doi.org/10.1038/sj.bjc.6603808 Text en Copyright © 2007 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Minireview Chidgey, M Dawson, C Desmosomes: a role in cancer? |
| title | Desmosomes: a role in cancer? |
| title_full | Desmosomes: a role in cancer? |
| title_fullStr | Desmosomes: a role in cancer? |
| title_full_unstemmed | Desmosomes: a role in cancer? |
| title_short | Desmosomes: a role in cancer? |
| title_sort | desmosomes: a role in cancer? |
| topic | Minireview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359958/ https://www.ncbi.nlm.nih.gov/pubmed/17519903 http://dx.doi.org/10.1038/sj.bjc.6603808 |
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